biostudies-literatureBlumenthaler ANHolly Clegg Gastric Cancer Research FundNCI NIH HHSNational Institutes of HealthNIH HHS911-922https://www.ebi.ac.uk/biostudies/studies/S-EPMC7906958biostudies-literatureUnknown123(4)<h4>Background and objectives</h4>We sought to evaluate the impact of lymphovascular invasion (LVI) and perineural invasion (PNI) on survival outcomes in gastric cancer patients treated with preoperative therapy.<h4>Methods</h4>Patients with gastric cancer treated with preoperative therapy and potentially curative resection were stratified according to the presence of LVI, PNI, or both. Kaplan-Meier and Cox regression analyses were used to evaluate the impact on overall survival (OS) and disease-free survival (DFS).<h4>Results</h4>The study included 281 patients, of whom 93 (33%) had LVI, 69 (25%) had PNI, 51 (18%) had both LVI and PNI, and 170 (61%) had neither. LVI and PNI were each associated with higher ypT and ypN categories and more positive lymph nodes (all p < .001), associations tJournal of surgical oncologyConcurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival.PMC7906958P30 CA016672T32 CA009599No Stomach For Cancer Award for Gastric Cancer ResAjani JABadgwell BDIkoma NNewhook TEMinsky BDMansfield PFEstrella JSDas PBlum Murphy MBlumenthaler ANfalseConcurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival.<h4>Background and objectives</h4>We sought to evaluate the impact of lymphovascular invasion (LVI) and perineural invasion (PNI) on survival outcomes in gastric cancer patients treated with preoperative therapy.<h4>Methods</h4>Patients with gastric cancer treated with preoperative therapy and potentially curative resection were stratified according to the presence of LVI, PNI, or both. Kaplan-Meier and Cox regression analyses were used to evaluate the impact on overall survival (OS) and disease-free survival (DFS).<h4>Results</h4>The study included 281 patients, of whom 93 (33%) had LVI, 69 (25%) had PNI, 51 (18%) had both LVI and PNI, and 170 (61%) had neither. LVI and PNI were each associated with higher ypT and ypN categories and more positive lymph nodes (all p < .001), associations t2021-01-01T00:00:00Z2021 Mar2025-04-04T19:53:49.586Z2025-04-04T19:53:49.586ZS-EPMC79069583340083810.1002/jso.26367