{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(3)"],"submitter":["Singh P"],"pubmed_abstract":["The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (<i>eNOS</i>), angiotensin converting enzyme (<i>ACE</i>) and vascular endothelial growth factor (<i>VEGFA</i>) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were examined for selected SNPs within <i>eNOS, ACE</i> and <i>VEGFA</i> genes. Linear regression analysis revealed a positive association of ED with bone mineral densities (BMDs) at femoral neck (r<sup>2</sup> = 0.78, <i>p</i> < 0.001) and lumbar spine (r<sup>2</sup> = 0.24, <i>p</i> = 0.001) after Bonferroni correction. Three susceptibili"],"journal":["International journal of environmental research and public health"],"pagination":["972"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7908366"],"repository":["biostudies-literature"],"pubmed_title":["Genetic Scores of <i>eNOS</i>, <i>ACE</i> and <i>VEGFA</i> Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women."],"pmcid":["PMC7908366"],"pubmed_authors":["Mastana S","Singh M","Valecha S","Juneja PK","Singh P","Kumar N","Khinda R","Singh S","Kaur T"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Scores of <i>eNOS</i>, <i>ACE</i> and <i>VEGFA</i> Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women.","description":"The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (<i>eNOS</i>), angiotensin converting enzyme (<i>ACE</i>) and vascular endothelial growth factor (<i>VEGFA</i>) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were examined for selected SNPs within <i>eNOS, ACE</i> and <i>VEGFA</i> genes. Linear regression analysis revealed a positive association of ED with bone mineral densities (BMDs) at femoral neck (r<sup>2</sup> = 0.78, <i>p</i> < 0.001) and lumbar spine (r<sup>2</sup> = 0.24, <i>p</i> = 0.001) after Bonferroni correction. Three susceptibili","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2025-04-05T12:01:49.639Z","creation":"2021-03-03T08:19:30Z"},"accession":"S-EPMC7908366","cross_references":{"pubmed":["33499313"],"doi":["10.3390/ijerph18030972"]}}