biostudies-literatureUnknown18(3)Singh PThe present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (<i>eNOS</i>), angiotensin converting enzyme (<i>ACE</i>) and vascular endothelial growth factor (<i>VEGFA</i>) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were examined for selected SNPs within <i>eNOS, ACE</i> and <i>VEGFA</i> genes. Linear regression analysis revealed a positive association of ED with bone mineral densities (BMDs) at femoral neck (r² = 0.78, <i>p</i> < 0.001) and lumbar spine (r² = 0.24, <i>p</i> = 0.001) after Bonferroni correction. Three susceptibiliInternational journal of environmental research and public health972https://www.ebi.ac.uk/biostudies/studies/S-EPMC7908366biostudies-literatureGenetic Scores of <i>eNOS</i>, <i>ACE</i> and <i>VEGFA</i> Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women.PMC7908366Mastana SSingh MValecha SJuneja PKSingh PKumar NKhinda RSingh SKaur TfalseGenetic Scores of <i>eNOS</i>, <i>ACE</i> and <i>VEGFA</i> Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women.The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (<i>eNOS</i>), angiotensin converting enzyme (<i>ACE</i>) and vascular endothelial growth factor (<i>VEGFA</i>) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were examined for selected SNPs within <i>eNOS, ACE</i> and <i>VEGFA</i> genes. Linear regression analysis revealed a positive association of ED with bone mineral densities (BMDs) at femoral neck (r² = 0.78, <i>p</i> < 0.001) and lumbar spine (r² = 0.24, <i>p</i> = 0.001) after Bonferroni correction. Three susceptibili2021-01-01T00:00:00Z2021 Jan2025-04-05T12:01:49.639Z2021-03-03T08:19:30ZS-EPMC79083663349931310.3390/ijerph18030972