{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu M"],"funding":["NHLBI NIH HHS"],"pagination":["318-330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7909333"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(3)"],"pubmed_abstract":["Pulmonary angiogenesis is a key driver of alveolarization. Our prior studies showed that NF-κB promotes pulmonary angiogenesis during early alveolarization. However, the mechanisms regulating temporal-specific NF-κB activation in the pulmonary vasculature are unknown. To identify mechanisms that activate proangiogenic NF-κB signaling in the developing pulmonary vasculature, proteomic analysis of the lung secretome was performed using two-dimensional difference gel electrophoresis. NF-κB activation and angiogenic function was assessed in primary pulmonary endothelial cells (PECs) and TGFBI (transforming growth factor-β-induced protein)-regulated genes identified using RNA sequencing. Alveolarization and pulmonary angiogenesis was assessed in wild-type and <i>Tgfbi</i> null mice exposed to n"],"journal":["American journal of respiratory cell and molecular biology"],"pubmed_title":["Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development."],"pmcid":["PMC7909333"],"funding_grant_id":["R01 HL122918","R01 HL110002","R01 HL148165"],"pubmed_authors":["Rao S","Fu S","Alvira CM","Dahl MJ","Liu M","Iosef C","Domingo-Gonzalez R","Conway SJ","Null DM","Umbach GS","Albertine KH","Heilshorn SC","Dewi RE","Snider P"],"additional_accession":[]},"is_claimable":false,"name":"Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.","description":"Pulmonary angiogenesis is a key driver of alveolarization. Our prior studies showed that NF-κB promotes pulmonary angiogenesis during early alveolarization. However, the mechanisms regulating temporal-specific NF-κB activation in the pulmonary vasculature are unknown. To identify mechanisms that activate proangiogenic NF-κB signaling in the developing pulmonary vasculature, proteomic analysis of the lung secretome was performed using two-dimensional difference gel electrophoresis. NF-κB activation and angiogenic function was assessed in primary pulmonary endothelial cells (PECs) and TGFBI (transforming growth factor-β-induced protein)-regulated genes identified using RNA sequencing. Alveolarization and pulmonary angiogenesis was assessed in wild-type and <i>Tgfbi</i> null mice exposed to n","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T19:54:05.586Z","creation":"2025-04-04T19:54:05.586Z"},"accession":"S-EPMC7909333","cross_references":{"pubmed":["33264084"],"doi":["10.1165/rcmb.2020-0153OC","10.1165/rcmb.2020-0153oc"]}}