{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sakuraba Y"],"funding":["MEXT | Japan Society for the Promotion of Science","MEXT | Japan Science and Technology Agency"],"pagination":["256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7910545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(1)"],"pubmed_abstract":["Identification of genes and their alleles capable of improving plant growth under low nitrogen (N) conditions is key for developing sustainable agriculture. Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots. Various analyses using accessions exhibiting reduced N deficiency responses revealed that enhanced NRT1.1 expression in shoots rather than in roots is responsible for better growth of Arabidopsis seedlings under N deficient conditions. Furthermore, polymorphisms that increased NRT1.1 promoter activity were identified in the NRT1.1 promoter sequences of th"],"journal":["Communications biology"],"pubmed_title":["Enhanced NRT1.1/NPF6.3 expression in shoots improves growth under nitrogen deficiency stress in Arabidopsis."],"pmcid":["PMC7910545"],"funding_grant_id":["JPMJCR 15O5","18H03940"],"pubmed_authors":["Iba K","Yanagisawa S","Mabuchi A","Sakuraba Y","Chaganzhana"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced NRT1.1/NPF6.3 expression in shoots improves growth under nitrogen deficiency stress in Arabidopsis.","description":"Identification of genes and their alleles capable of improving plant growth under low nitrogen (N) conditions is key for developing sustainable agriculture. Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots. Various analyses using accessions exhibiting reduced N deficiency responses revealed that enhanced NRT1.1 expression in shoots rather than in roots is responsible for better growth of Arabidopsis seedlings under N deficient conditions. Furthermore, polymorphisms that increased NRT1.1 promoter activity were identified in the NRT1.1 promoter sequences of th","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-04T22:01:22.591Z","creation":"2025-04-04T22:01:22.591Z"},"accession":"S-EPMC7910545","cross_references":{"pubmed":["33637855"],"doi":["10.1038/s42003-021-01775-1"]}}