biostudies-literatureKusunose KTakeda Science FoundationPublic Trust Cardiovascular Research FundJapan Society for the Promotion of Science335https://www.ebi.ac.uk/biostudies/studies/S-EPMC7911510biostudies-literatureUnknown13(2)A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementatioNutrientsAssociation between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals.PMC7911510N/A19H0365420K17084Wakatsuki TOkayama YSata MZheng RYamada HSoeki TOkushi YNakai MAbe MIse TTobiume TKusunose KYagi SFukuda DSumita YYamaguchi KfalseAssociation between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals.A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementatio2021-01-01T00:00:00Z2021 Jan2025-05-29T22:28:25.342Z2025-05-29T22:28:25.342ZS-EPMC79115103349870910.3390/nu13020335