{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jandova J"],"funding":["National Institutes of Health"],"pagination":["605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7913703"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["There are two stable isotopes of hydrogen, protium (1H) and deuterium (2H; D). Cellular stress response dysregulation in cancer represents both a major pathological driving force and a promising therapeutic target, but the molecular consequences and potential therapeutic impact of deuterium (2H)-stress on cancer cells remain largely unexplored. We have examined the anti-proliferative and apoptogenic effects of deuterium oxide (D2O; 'heavy water') together with stress response gene expression profiling in panels of malignant melanoma (A375V600E, A375NRAS, G361, LOX-IMVI), and pancreatic ductal adenocarcinoma (PANC-1, Capan-2, or MIA PaCa-2) cells with inclusion of human diploid Hs27 skin fibroblasts. Moreover, we have examined the efficacy of D2O-based pharmacological intervention in murine"],"journal":["Cancers"],"pubmed_title":["Deuterium Oxide (D2O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma."],"pmcid":["PMC7913703"],"funding_grant_id":["R01CA229418","ES007091","R21ES029579","ES006694","R03CA230949","CA023074","P01CA229112"],"pubmed_authors":["Hua AB","Jandova J","Fimbres J","Wondrak GT"],"additional_accession":[]},"is_claimable":false,"name":"Deuterium Oxide (D2O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant Melanoma.","description":"There are two stable isotopes of hydrogen, protium (1H) and deuterium (2H; D). Cellular stress response dysregulation in cancer represents both a major pathological driving force and a promising therapeutic target, but the molecular consequences and potential therapeutic impact of deuterium (2H)-stress on cancer cells remain largely unexplored. We have examined the anti-proliferative and apoptogenic effects of deuterium oxide (D2O; 'heavy water') together with stress response gene expression profiling in panels of malignant melanoma (A375V600E, A375NRAS, G361, LOX-IMVI), and pancreatic ductal adenocarcinoma (PANC-1, Capan-2, or MIA PaCa-2) cells with inclusion of human diploid Hs27 skin fibroblasts. Moreover, we have examined the efficacy of D2O-based pharmacological intervention in murine","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-05-29T22:28:25.599Z","creation":"2021-03-02T08:09:11Z"},"accession":"S-EPMC7913703","cross_references":{"pubmed":["33546433"],"doi":["10.3390/cancers13040605"]}}