{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Faurholt-Jepsen M"],"funding":["Listed in the manuscript"],"pubmed_abstract":["<h4>Objective</h4>The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) experience daily stress, mood instability (MI) and studies have shown disrupted HPA-axis dynamics.<h4>Aims</h4>to evaluate (1) patient-evaluated stress against the CAR, (2) associations between the CAR and mood symptoms, and (3) the effect of smartphone-based treatment on the CAR.<h4>Methods</h4>Patients with BD (n = 67) were randomized to the use of daily smartphone-based monitoring (the intervention group) or to the control group for six months. Clinically rated symptoms according to the Hamilton Depression Rating Scale 17-items (HDRS), the Young Mania Rating Scale (Y"],"journal":["International journal of bipolar disorders"],"pagination":["8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7917033"],"repository":["biostudies-literature"],"pubmed_title":["Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study."],"pmcid":["PMC7917033"],"pubmed_authors":["Kessing LV","Vinberg M","Faurholt-Jepsen M","Nasser A","Jorgensen NR","Frokjær VG"],"additional_accession":[]},"is_claimable":false,"name":"Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study.","description":"<h4>Objective</h4>The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) experience daily stress, mood instability (MI) and studies have shown disrupted HPA-axis dynamics.<h4>Aims</h4>to evaluate (1) patient-evaluated stress against the CAR, (2) associations between the CAR and mood symptoms, and (3) the effect of smartphone-based treatment on the CAR.<h4>Methods</h4>Patients with BD (n = 67) were randomized to the use of daily smartphone-based monitoring (the intervention group) or to the control group for six months. Clinically rated symptoms according to the Hamilton Depression Rating Scale 17-items (HDRS), the Young Mania Rating Scale (Y","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T11:37:31.783Z","creation":"2025-02-19T01:06:49.802Z"},"accession":"S-EPMC7917033","cross_references":{"pubmed":["33644824"],"doi":["10.1186/s40345-020-00214-0"]}}