biostudies-literatureUnknown9(1)Faurholt-Jepsen MListed in the manuscript<h4>Objective</h4>The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) experience daily stress, mood instability (MI) and studies have shown disrupted HPA-axis dynamics.<h4>Aims</h4>to evaluate (1) patient-evaluated stress against the CAR, (2) associations between the CAR and mood symptoms, and (3) the effect of smartphone-based treatment on the CAR.<h4>Methods</h4>Patients with BD (n = 67) were randomized to the use of daily smartphone-based monitoring (the intervention group) or to the control group for six months. Clinically rated symptoms according to the Hamilton Depression Rating Scale 17-items (HDRS), the Young Mania Rating Scale (YInternational journal of bipolar disorders8https://www.ebi.ac.uk/biostudies/studies/S-EPMC7917033biostudies-literatureAssociations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study.PMC7917033Kessing LVVinberg MFaurholt-Jepsen MNasser AJorgensen NRFrokjær VGfalseAssociations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study.<h4>Objective</h4>The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) experience daily stress, mood instability (MI) and studies have shown disrupted HPA-axis dynamics.<h4>Aims</h4>to evaluate (1) patient-evaluated stress against the CAR, (2) associations between the CAR and mood symptoms, and (3) the effect of smartphone-based treatment on the CAR.<h4>Methods</h4>Patients with BD (n = 67) were randomized to the use of daily smartphone-based monitoring (the intervention group) or to the control group for six months. Clinically rated symptoms according to the Hamilton Depression Rating Scale 17-items (HDRS), the Young Mania Rating Scale (Y2021-01-01T00:00:00Z2021 Mar2025-04-04T11:37:31.783Z2025-02-19T01:06:49.802ZS-EPMC79170333364482410.1186/s40345-020-00214-0