{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mohamed H"],"funding":["Drexel University Office of Global Engagement and Education Abroad","Drexel University College of Medicine, Department of Microbiology & Immunology and Institute for Molecular Medicine and Infectious Disease","German Federal Ministry of Education and Research"],"pagination":["e0247125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7920340"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["Effective control of infection by human immunodeficiency virus type 1 (HIV-1), the causative agent of the acquired immunodeficiency syndrome (AIDS), requires continuous and life-long use of anti-retroviral therapy (ART) by people living with HIV-1 (PLWH). In the absence of ART, HIV-1 reemergence from latently infected cells is ineffectively suppressed due to suboptimal innate and cytotoxic T lymphocyte responses. However, ART-free control of HIV-1 infection may be possible if the inherent immunological deficiencies can be reversed or restored. Herein we present a novel approach for modulating the immune response to HIV-1 that involves the use of non-thermal plasma (NTP), which is an ionized gas containing various reactive oxygen and nitrogen species (RONS). J-Lat cells were used as a model"],"journal":["PloS one"],"pubmed_title":["Non-thermal plasma modulates cellular markers associated with immunogenicity in a model of latent HIV-1 infection."],"pmcid":["PMC7920340"],"funding_grant_id":["03Z22DN11","03Z22DN12","03Z22Di1"],"pubmed_authors":["Freund E","Connors J","Dampier W","Bekeschus S","Haddad EK","Wigdahl B","Clemen R","Lackmann JW","Wende K","Miller V","Mohamed H","Krebs FC"],"additional_accession":[]},"is_claimable":false,"name":"Non-thermal plasma modulates cellular markers associated with immunogenicity in a model of latent HIV-1 infection.","description":"Effective control of infection by human immunodeficiency virus type 1 (HIV-1), the causative agent of the acquired immunodeficiency syndrome (AIDS), requires continuous and life-long use of anti-retroviral therapy (ART) by people living with HIV-1 (PLWH). In the absence of ART, HIV-1 reemergence from latently infected cells is ineffectively suppressed due to suboptimal innate and cytotoxic T lymphocyte responses. However, ART-free control of HIV-1 infection may be possible if the inherent immunological deficiencies can be reversed or restored. Herein we present a novel approach for modulating the immune response to HIV-1 that involves the use of non-thermal plasma (NTP), which is an ionized gas containing various reactive oxygen and nitrogen species (RONS). J-Lat cells were used as a model","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T01:15:27.083Z","creation":"2021-03-13T08:21:23Z"},"accession":"S-EPMC7920340","cross_references":{"pubmed":["33647028"],"doi":["10.1371/journal.pone.0247125"]}}