{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei H"],"funding":["NEI NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["108721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7920574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(5)"],"pubmed_abstract":["Spinal cord injury (SCI) is one of the most devastating neural injuries without effective therapeutic solutions. Astrocytes are the predominant component of the scar. Understanding the complex contributions of reactive astrocytes to SCI pathophysiologies is fundamentally important for developing therapeutic strategies. We have studied the molecular changes in the injury environment and the astrocyte-specific responses by astrocyte purification from injured spinal cords from acute to chronic stages. In addition to protein-coding genes, we have systematically analyzed the expression profiles of long non-coding RNAs (lncRNAs) (>200 bp), which are regulatory RNAs that play important roles in the CNS. We have identified a highly conserved lncRNA, Zeb2os, and demonstrated using functional assays"],"journal":["Cell reports"],"pubmed_title":["Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis."],"pmcid":["PMC7920574"],"funding_grant_id":["R21 NS113068","R01 NS099635","R21 EY028647","R01 NS088353"],"pubmed_authors":["Kim DH","You Y","Zheng Y","Narayanan KL","Li X","Prajapati TJ","Cao QL","Hai B","Wu JQ","Tallapragada N","Duran RC","Wei H","Deneen B","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.","description":"Spinal cord injury (SCI) is one of the most devastating neural injuries without effective therapeutic solutions. Astrocytes are the predominant component of the scar. Understanding the complex contributions of reactive astrocytes to SCI pathophysiologies is fundamentally important for developing therapeutic strategies. We have studied the molecular changes in the injury environment and the astrocyte-specific responses by astrocyte purification from injured spinal cords from acute to chronic stages. In addition to protein-coding genes, we have systematically analyzed the expression profiles of long non-coding RNAs (lncRNAs) (>200 bp), which are regulatory RNAs that play important roles in the CNS. We have identified a highly conserved lncRNA, Zeb2os, and demonstrated using functional assays","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-05-03T01:43:33.356Z","creation":"2021-03-05T09:03:30Z"},"accession":"S-EPMC7920574","cross_references":{"pubmed":["33535036"],"doi":["10.1016/j.celrep.2021.108721"]}}