{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Urban RD"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["1561-1570"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7921053"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["413(6)"],"pubmed_abstract":["By the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates this free liquid jet consisting of water as the continuous phase and the non-polar solvent as the dispersed droplet phase, the solutes in the droplets are ionized. This ionization at atmospheric pressure enables the mass spectrometric analysis of non-polar compounds with the aid of a surrounding aqueous matrix that absorbs IR light. This works both for non-polar solvents such as n-heptane and for water non-miscible solvents like chloroform. In a proof of concept study, this approach is applied to monitor a photooxidation of N-phenyl-1,2,3,4-tetrahydroisoquinoline. By using water as an infrared absorbing matrix, analytes, dissolved in non-polar solvents from reactions carried out on a microchip, can be desorbed and ionized for investigation by mass spectrometry."],"journal":["Analytical and bioanalytical chemistry"],"pubmed_title":["On-chip mass spectrometric analysis in non-polar solvents by liquid beam infrared matrix-assisted laser dispersion/ionization."],"pmcid":["PMC7921053"],"funding_grant_id":["ZE 717/7-1"],"pubmed_authors":["Charvat A","Fischer TG","Belder D","Abel B","Zeitler K","Wink K","Ohla S","Urban RD","Krafft B"],"additional_accession":[]},"is_claimable":false,"name":"On-chip mass spectrometric analysis in non-polar solvents by liquid beam infrared matrix-assisted laser dispersion/ionization.","description":"By the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates this free liquid jet consisting of water as the continuous phase and the non-polar solvent as the dispersed droplet phase, the solutes in the droplets are ionized. This ionization at atmospheric pressure enables the mass spectrometric analysis of non-polar compounds with the aid of a surrounding aqueous matrix that absorbs IR light. This works both for non-polar solvents such as n-heptane and for water non-miscible solvents like chloroform. In a proof of concept study, this approach is applied to monitor a photooxidation of N-phenyl-1,2,3,4-tetrahydroisoquinoline. By using water as an infrared absorbing matrix, analytes, dissolved in non-polar solvents from reactions carried out on a microchip, can be desorbed and ionized for investigation by mass spectrometry.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-20T02:27:37.052Z","creation":"2025-04-20T02:27:37.052Z"},"accession":"S-EPMC7921053","cross_references":{"pubmed":["33479818"],"doi":["10.1007/s00216-020-03115-4"]}}