{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Mangili F"],"funding":["Associazione Italiana per la Ricerca sul Cancro"],"pubmed_abstract":["The actin binding protein filamin A (FLNA) is required for somatostatin receptor 2 (SSTR2) and dopamine receptor 2 (DRD2) expression and signaling in GH- and PRL-secreting PitNETs, respectively, playing a role in tumor responsiveness to somatostatin receptors ligands and dopaminergic drugs. FLNA functions are regulated by several mechanisms, including phosphorylation. It has been shown that in GH-secreting PitNETs FLNA phosphorylation on Ser2152 (P-FLNA) switches FLNA function from a scaffold that allows SSTR2 signal transduction, to a signal termination protein that hampers SSTR2 antitumoral effects. Aims of the present study were to evaluate in PRL- and ACTH-secreting PitNETs cell lines MMQ and AtT-20 the effects of cAMP pathway activation and DRD2 agonist on P-FLNA and the impact of P-F"],"journal":["Frontiers in endocrinology"],"pagination":["611752"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7921166"],"repository":["biostudies-literature"],"pubmed_title":["A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation."],"pmcid":["PMC7921166"],"pubmed_authors":["Peverelli E","Catalano R","Marra G","Mantovani G","Arosio M","Treppiedi D","Spada A","Di Muro G","Mangili F"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.","description":"The actin binding protein filamin A (FLNA) is required for somatostatin receptor 2 (SSTR2) and dopamine receptor 2 (DRD2) expression and signaling in GH- and PRL-secreting PitNETs, respectively, playing a role in tumor responsiveness to somatostatin receptors ligands and dopaminergic drugs. FLNA functions are regulated by several mechanisms, including phosphorylation. It has been shown that in GH-secreting PitNETs FLNA phosphorylation on Ser2152 (P-FLNA) switches FLNA function from a scaffold that allows SSTR2 signal transduction, to a signal termination protein that hampers SSTR2 antitumoral effects. Aims of the present study were to evaluate in PRL- and ACTH-secreting PitNETs cell lines MMQ and AtT-20 the effects of cAMP pathway activation and DRD2 agonist on P-FLNA and the impact of P-F","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T11:54:20.16Z","creation":"2021-03-09T08:11:35Z"},"accession":"S-EPMC7921166","cross_references":{"pubmed":["33664708"],"doi":["10.3389/fendo.2020.611752"]}}