{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan Q"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS","NIMHD NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["933-940"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7921212"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["147(3)"],"pubmed_abstract":["<h4>Background</h4>Little is known about the genetic determinants of severe asthma exacerbations.<h4>Objectives</h4>We aimed to identify genetic variants associated with asthma hospitalizations.<h4>Methods</h4>We conducted a genome-wide association study of asthma hospitalizations in 34,167 white British adults with asthma, 1,658 of whom had at least 1 asthma-related hospitalization. This analysis was conducted by using logistic regression under an additive genetic model with adjustment for age, sex, body mass index, smoking status, and the first 5 principal components derived from genotypic data. We then analyzed data from 2 cohorts of Latino children and adolescents for replication and conducted quantitative trait locus and functional annotation analyses.<h4>Results</h4>At the chromosome"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["A genome-wide association study of asthma hospitalizations in adults."],"pmcid":["PMC7921212"],"funding_grant_id":["R01 MD011764","R01 HL117004","R01 HL079966","U54 GM133807","U54 MD007587","R01 ES015794","K01 HL138098","R01 HL117191"],"pubmed_authors":["Huntsman S","Cloutier MM","Pino-Yanes M","Yang G","Yan Q","Burchard EG","Rodriguez-Santana JR","Oh S","Celedon JC","Hu D","Acosta-Perez E","Forno E","Chen W","Canino G","Herrera-Luis E","Eng C"],"additional_accession":[]},"is_claimable":false,"name":"A genome-wide association study of asthma hospitalizations in adults.","description":"<h4>Background</h4>Little is known about the genetic determinants of severe asthma exacerbations.<h4>Objectives</h4>We aimed to identify genetic variants associated with asthma hospitalizations.<h4>Methods</h4>We conducted a genome-wide association study of asthma hospitalizations in 34,167 white British adults with asthma, 1,658 of whom had at least 1 asthma-related hospitalization. This analysis was conducted by using logistic regression under an additive genetic model with adjustment for age, sex, body mass index, smoking status, and the first 5 principal components derived from genotypic data. We then analyzed data from 2 cohorts of Latino children and adolescents for replication and conducted quantitative trait locus and functional annotation analyses.<h4>Results</h4>At the chromosome","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-30T23:53:32.483Z","creation":"2025-04-05T10:03:47.04Z"},"accession":"S-EPMC7921212","cross_references":{"pubmed":["32890573"],"doi":["10.1016/j.jaci.2020.08.020"]}}