{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["George SHL"],"funding":["NIMHD NIH HHS","NCI NIH HHS"],"pagination":["e210307"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7921902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(3)"],"pubmed_abstract":["<h4>Importance</h4>Rates of breast and ovarian cancer are high in the Caribbean; however, to date, few published data quantify the prevalence of inherited cancer in the Caribbean population.<h4>Objective</h4>To determine whether deleterious variants in genes that characterize the hereditary breast and ovarian cancer syndrome are associated with the development of breast and ovarian cancer in the English- and Creole-speaking Caribbean populations.<h4>Design, setting, and participants</h4>This multisite genetic association study used data from germline genetic test results between June 2010 and June 2018 in the Bahamas, Cayman Islands, Barbados, Dominica, Jamaica, Haiti, and Trinidad and Tobago. Next-generation sequencing on a panel of 30 genes and multiplex ligation-dependent probe amplific"],"journal":["JAMA network open"],"pubmed_title":["Gene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean."],"pmcid":["PMC7921902"],"funding_grant_id":["L60 MD014321","P30 CA240139"],"pubmed_authors":["Hurley JE","Chin SN","Wharfe G","Curling D","Yin S","Barreto-Coelho P","Lunn J","Dyer H","DeGennaro V","Ali J","Butler R","Cerbon D","Narod SA","Lowe D","Schlumbrecht MP","Alexis C","Akbari MR","Donenberg T","Turnquest T","George SHL"],"additional_accession":[]},"is_claimable":false,"name":"Gene Sequencing for Pathogenic Variants Among Adults With Breast and Ovarian Cancer in the Caribbean.","description":"<h4>Importance</h4>Rates of breast and ovarian cancer are high in the Caribbean; however, to date, few published data quantify the prevalence of inherited cancer in the Caribbean population.<h4>Objective</h4>To determine whether deleterious variants in genes that characterize the hereditary breast and ovarian cancer syndrome are associated with the development of breast and ovarian cancer in the English- and Creole-speaking Caribbean populations.<h4>Design, setting, and participants</h4>This multisite genetic association study used data from germline genetic test results between June 2010 and June 2018 in the Bahamas, Cayman Islands, Barbados, Dominica, Jamaica, Haiti, and Trinidad and Tobago. Next-generation sequencing on a panel of 30 genes and multiplex ligation-dependent probe amplific","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-20T02:27:21.413Z","creation":"2025-04-20T02:27:21.413Z"},"accession":"S-EPMC7921902","cross_references":{"pubmed":["33646313"],"doi":["10.1001/jamanetworkopen.2021.0307"]}}