biostudies-literatureUnknownLe TT<h4>Objective</h4>Neurological complications can worsen outcomes in COVID-19. We defined the prevalence of a wide range of neurological conditions among patients hospitalized with COVID-19 in geographically diverse multinational populations.<h4>Methods</h4>Using electronic health record (EHR) data from 348 participating hospitals across 6 countries and 3 continents between January and September 2020, we performed a cross-sectional study of hospitalized adult and pediatric patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test, both with and without severe COVID-19. We assessed the frequency of each disease category and 3-character International Classification of Disease (ICD) code of neurological diseases by countries, sites, time before and after admission for COVID-19, and COVID-19 severity.<h4>Results</h4>Among the 35,177 hospitalized patients with SARS-CoV-2 infection, there was increased prevalence of disorders of consciousness (5.8%, 95% confidence interval [CI]: 3.7%-7.8%, <i>p</i> _FDR <.001) and unspecified disorders of the brain (8.1%, 95%CI: 5.7%-10.5%, <i>p</i> _FDR <.001), compared to pre-admission prevalence. During hospitalization, patients who experienced severe COVID-19 status had 22% (95%CI: 19%-25%) increase in the relative risk (RR) of disorders of consciousness, 24% (95%CI: 13%-35%) increase in other cerebrovascular diseases, 34% (95%CI: 20%-50%) increase in nontraumatic intracranial hemorrhage, 37% (95%CI: 17%-60%) increase in encephalitis and/or myelitis, and 72% (95%CI: 67%-77%) increase in myopathy compared to those who never experienced severe disease.<h4>Interpretation</h4>Using an international network and common EHR data elements, we highlight an increase in the prevalence of central and peripheral neurological phenotypes in patients hospitalized with SARS-CoV-2 infection, particularly among those with severe disease.medRxiv : the preprint server for health scienceshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC7924306biostudies-literatureMultinational Prevalence of Neurological Phenotypes in Patients Hospitalized with COVID-19.PMC7924306Ngiam KYCai TXia ZVisweswaran SMowery DLBeaulieu-Jones BKTan ALLoh NHWHong CKohane ISSouth AMMoore JSamayamuthu MJMorris MPatel LPSon JLe TTLuo YSchriver EOmenn GSAvillach PGutierrez-Sacristan AfalseMultinational Prevalence of Neurological Phenotypes in Patients Hospitalized with COVID-19.<h4>Objective</h4>Neurological complications can worsen outcomes in COVID-19. We defined the prevalence of a wide range of neurological conditions among patients hospitalized with COVID-19 in geographically diverse multinational populations.<h4>Methods</h4>Using electronic health record (EHR) data from 348 participating hospitals across 6 countries and 3 continents between January and September 2020, we performed a cross-sectional study of hospitalized adult and pediatric patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test, both with and without severe COVID-19. We assessed the frequency of each disease category and 3-character International Classification of Disease (ICD) code of neurological diseases by countries, sites, time before and after admission for COVID-19, and COVID-19 severity.<h4>Results</h4>Among the 35,177 hospitalized patients with SARS-CoV-2 infection, there was increased prevalence of disorders of consciousness (5.8%, 95% confidence interval [CI]: 3.7%-7.8%, <i>p</i> _FDR <.001) and unspecified disorders of the brain (8.1%, 95%CI: 5.7%-10.5%, <i>p</i> _FDR <.001), compared to pre-admission prevalence. During hospitalization, patients who experienced severe COVID-19 status had 22% (95%CI: 19%-25%) increase in the relative risk (RR) of disorders of consciousness, 24% (95%CI: 13%-35%) increase in other cerebrovascular diseases, 34% (95%CI: 20%-50%) increase in nontraumatic intracranial hemorrhage, 37% (95%CI: 17%-60%) increase in encephalitis and/or myelitis, and 72% (95%CI: 67%-77%) increase in myopathy compared to those who never experienced severe disease.<h4>Interpretation</h4>Using an international network and common EHR data elements, we highlight an increase in the prevalence of central and peripheral neurological phenotypes in patients hospitalized with SARS-CoV-2 infection, particularly among those with severe disease.2021-01-01T00:00:00Z2021 Jan2021-03-12T08:17:46Z2021-03-12T08:17:46ZS-EPMC79243063365528110.1101/2021.01.27.21249817