biostudies-literature00710Unknown45(1)GUngOr TA series of novel imidazo[1,2- <i>a</i> ]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2- <i>a</i> ]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by <i>p</i> -toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2- <i>a</i> ]pyrimidine containing tri/tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, ¹H NMR, ¹³ C NMR, and MS.Turkish journal of chemistry219-230https://www.ebi.ac.uk/biostudies/studies/S-EPMC7925308biostudies-literatureMicrowave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives.PMC7925308GUngOr T71falseMicrowave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives.A series of novel imidazo[1,2- <i>a</i> ]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2- <i>a</i> ]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by <i>p</i> -toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2- <i>a</i> ]pyrimidine containing tri/tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, ¹H NMR, ¹³ C NMR, and MS.2021-01-01T00:00:00Z20212024-11-13T04:32:17.838Z2021-03-12T08:19:48ZS-EPMC79253083367916510.3906/kim-2009-40