biostudies-literatureAbdelrazig SVersus ArthritisFP7 HealthArithritis Research UK29https://www.ebi.ac.uk/biostudies/studies/S-EPMC7925472biostudies-literatureUnknown17(3)<h4>Introduction</h4>Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology of OA.<h4>Objectives</h4>To investigate possible surrogate biomarkers of knee OA in urine using metabolomics to contribute towards a better understanding of OA progression and possible targeted treatment.<h4>Method</h4>Liquid chromatography-high resolution mass spectrometry (LC-HRMS) was applied in a case-control approach to explore the possible metabolic differences between the urinary profiles of symptomatic knee OA patients (n = 74) (subclassified into inflammatory OA, n = 22 and non-inflammatory OA, n = 52) and non-OA controls (n = Metabolomics : Official journal of the Metabolomic SocietyMetabolic signatures of osteoarthritis in urine using liquid chromatography-high resolution tandem mass spectrometry.PMC792547230581518769, 207772077718769Chapman VDoherty MValdes AMAbdelrazig SBarrett DAOrtori CAfalseMetabolic signatures of osteoarthritis in urine using liquid chromatography-high resolution tandem mass spectrometry.<h4>Introduction</h4>Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology of OA.<h4>Objectives</h4>To investigate possible surrogate biomarkers of knee OA in urine using metabolomics to contribute towards a better understanding of OA progression and possible targeted treatment.<h4>Method</h4>Liquid chromatography-high resolution mass spectrometry (LC-HRMS) was applied in a case-control approach to explore the possible metabolic differences between the urinary profiles of symptomatic knee OA patients (n = 74) (subclassified into inflammatory OA, n = 22 and non-inflammatory OA, n = 52) and non-OA controls (n = 2021-01-01T00:00:00Z2021 Mar2025-04-05T22:31:28.84Z2025-04-05T22:31:28.84ZS-EPMC79254723365541810.1007/s11306-021-01778-3