{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCann JR"],"funding":["American Heart Association","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["569-578"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7927749"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(3)"],"pubmed_abstract":["<h4>Objective</h4>The purpose of this study was to establish a biorepository of clinical, metabolomic, and microbiome samples from adolescents with obesity as they undergo lifestyle modification.<h4>Methods</h4>A total of 223 adolescents aged 10 to 18 years with BMI ≥95th percentile were enrolled, along with 71 healthy weight participants. Clinical data, fasting serum, and fecal samples were collected at repeated intervals over 6 months. Herein, the study design, data collection methods, and interim analysis-including targeted serum metabolite measurements and fecal 16S ribosomal RNA gene amplicon sequencing among adolescents with obesity (n = 27) and healthy weight controls (n = 27)-are presented.<h4>Results</h4>Adolescents with obesity have higher serum alanine aminotransferase, C-reacti"],"journal":["Obesity (Silver Spring, Md.)"],"pubmed_title":["The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights."],"pmcid":["PMC7927749"],"funding_grant_id":["K23 DK120960","R24 DK110492","R24‐DK110492","17SFRN33670990"],"pubmed_authors":["Catherine C","Wootton J","Roche K","Arlotto M","McCann JR","Granek JA","Wei Z","Silverman J","Jawahar J","Ilkayeva O","Zizzi A","Armstrong SC","Sarria C","Seed PC","Newgard CB","David LA","Poppe L","Kwee LC","Dressman HK","Bihlmeyer NA","Valdivia RH","Anderson P","Rawls JF","Shah SH","Younge NE"],"additional_accession":[]},"is_claimable":false,"name":"The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.","description":"<h4>Objective</h4>The purpose of this study was to establish a biorepository of clinical, metabolomic, and microbiome samples from adolescents with obesity as they undergo lifestyle modification.<h4>Methods</h4>A total of 223 adolescents aged 10 to 18 years with BMI ≥95th percentile were enrolled, along with 71 healthy weight participants. Clinical data, fasting serum, and fecal samples were collected at repeated intervals over 6 months. Herein, the study design, data collection methods, and interim analysis-including targeted serum metabolite measurements and fecal 16S ribosomal RNA gene amplicon sequencing among adolescents with obesity (n = 27) and healthy weight controls (n = 27)-are presented.<h4>Results</h4>Adolescents with obesity have higher serum alanine aminotransferase, C-reacti","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-30T16:51:10.885Z","creation":"2024-12-04T03:36:02.046Z"},"accession":"S-EPMC7927749","cross_references":{"pubmed":["33624438"],"doi":["10.1002/oby.23081"]}}