biostudies-literatureScourfield DOKenneth Rainin FoundationVersus ArthritisMedical Research CouncilKennedy TrustWellcome Trustiqab003https://www.ebi.ac.uk/biostudies/studies/S-EPMC7928637biostudies-literatureUnknown2(1)Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity.Oxford open immunologyThe role and uses of antibodies in COVID-19 infections: a living review.PMC7928637KENN202111MR/M008614/2G0000635KRA000116KENN161708KENN202113211122/Z/18/ZKENN15160621546Compeer EBRodrigues PRSSami ASelvakumar TACrespo ATSimon AKOxford-Cardiff COVID-19 Literature ConsortiumLauder SNHanna SJBezbradica JSCifuentes LDimonte SGodkin ARobinson AJBBayliss RThornton EDyer AIssa FMazet JMvan Grinsven EAhern DJAlonzi DSBorst RLigoxygakis PFischer FWilliams RSmith ALSchonfeldova BZhu ZHulin-Curtis SAlrubayyi AJones EReed SJames Matthews RScourfield DOQuastel MAlsaleh GFielding CZhou DGalloway SCross AGammage ACapitani LSabberwal PBorsa MUhl LFKShepherd FRPeres RSMarzeda AMLiddiard KShorten CDendrou CAMacLachlan BAlderson JGallimore AMitchell EMaleki-Toyserkani SNguyen VDBurnell SEARichmond NBerthold DLWilson JDEleonore Pavillet CPeter Durairaj RRCavounidis AChauveau ADavies LCO'Hanlon MCodd ASMoon OCoveney CLu FDanielli SJones RBharuchq TSattentau QHeuberger CGea-Mallorqui EMann EHDustin LBPring EReed SGBorrmann HPires AWann AKTTeijeira Crespo AAlmuttaqi HMilicic ABrun JRichter FCBatchelor VBart VMTPeppa DTellier MLadell KChapman LRehwinkel JfalseThe role and uses of antibodies in COVID-19 infections: a living review.Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity.2021-01-01T00:00:00Z20212025-05-18T11:26:03.598Z2021-03-08T08:09:28ZS-EPMC79286373419227010.1093/oxfimm/iqab003