{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taz TA"],"funding":["National Science, Technology and Innovation Plan","King Abdul-Aziz City for Science and Technology"],"pagination":["1451-1465"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7929374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(2)"],"pubmed_abstract":["This study aimed to identify significant gene expression profiles of the human lung epithelial cells caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We performed a comparative genomic analysis to show genomic observations between SARS-CoV and SARS-CoV-2. A phylogenetic tree has been carried for genomic analysis that confirmed the genomic variance between SARS-CoV and SARS-CoV-2. Transcriptomic analyses have been performed for SARS-CoV-2 infection responses and pulmonary arterial hypertension (PAH) patients' lungs as a number of patients have been identified who faced PAH after being diagnosed with coronavirus disease 2019 (COVID-19). Gene expression profiling showed significant expression levels for SARS-CoV-2 infection responses to human lung epithelial "],"journal":["Briefings in bioinformatics"],"pubmed_title":["Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients."],"pmcid":["PMC7929374"],"funding_grant_id":["12-INF2970-10"],"pubmed_authors":["Taz TA","Mahmud SMH","Paul BK","Ahmed K","Al-Zahrani FA","Moni MA"],"additional_accession":[]},"is_claimable":false,"name":"Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients.","description":"This study aimed to identify significant gene expression profiles of the human lung epithelial cells caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We performed a comparative genomic analysis to show genomic observations between SARS-CoV and SARS-CoV-2. A phylogenetic tree has been carried for genomic analysis that confirmed the genomic variance between SARS-CoV and SARS-CoV-2. Transcriptomic analyses have been performed for SARS-CoV-2 infection responses and pulmonary arterial hypertension (PAH) patients' lungs as a number of patients have been identified who faced PAH after being diagnosed with coronavirus disease 2019 (COVID-19). Gene expression profiling showed significant expression levels for SARS-CoV-2 infection responses to human lung epithelial ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-05-18T11:26:33.634Z","creation":"2021-03-08T08:09:31Z"},"accession":"S-EPMC7929374","cross_references":{"pubmed":["33611340"],"doi":["10.1093/bib/bbab026"]}}