{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McNamara MP"],"funding":["University of California, Riverside Academic Senate","National Institutes of Health","National Science Foundation"],"pagination":["jeb239699"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7929929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["224(Pt 4)"],"pubmed_abstract":["Alterations to the gut microbiome caused by changes in diet, consumption of antibiotics, etc., can affect host function. Moreover, perturbation of the microbiome during critical developmental periods potentially has long-lasting impacts on hosts. Using four selectively bred high runner and four non-selected control lines of mice, we examined the effects of early-life diet and exercise manipulations on the adult microbiome by sequencing the hypervariable internal transcribed spacer region of the bacterial gut community. Mice from high runner lines run ∼3-fold more on wheels than do controls, and have several other phenotypic differences (e.g. higher food consumption and body temperature) that could alter the microbiome, either acutely or in terms of coevolution. Males from generation 76 wer"],"journal":["The Journal of experimental biology"],"pubmed_title":["Early-life effects of juvenile Western diet and exercise on adult gut microbiome composition in mice."],"pmcid":["PMC7929929"],"funding_grant_id":["DEB 1655362","R21HD084856"],"pubmed_authors":["Ruegger PM","Singleton JM","McNamara MP","Cadney MD","Borneman J","Garland T"],"additional_accession":[]},"is_claimable":false,"name":"Early-life effects of juvenile Western diet and exercise on adult gut microbiome composition in mice.","description":"Alterations to the gut microbiome caused by changes in diet, consumption of antibiotics, etc., can affect host function. Moreover, perturbation of the microbiome during critical developmental periods potentially has long-lasting impacts on hosts. Using four selectively bred high runner and four non-selected control lines of mice, we examined the effects of early-life diet and exercise manipulations on the adult microbiome by sequencing the hypervariable internal transcribed spacer region of the bacterial gut community. Mice from high runner lines run ∼3-fold more on wheels than do controls, and have several other phenotypic differences (e.g. higher food consumption and body temperature) that could alter the microbiome, either acutely or in terms of coevolution. Males from generation 76 wer","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-05-18T12:33:15.256Z","creation":"2025-04-04T10:16:09.85Z"},"accession":"S-EPMC7929929","cross_references":{"pubmed":["33431595"],"doi":["10.1242/jeb.239699"]}}