{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Chen L"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["The basal forebrain cholinergic system is involved in cognitive processes, but the role of the basal forebrain cholinergic system in depression is unknown. We investigated whether a lesion of cholinergic neurons in the horizontal limb of the diagonal band of Broca (HDB) produces depressive-like behavior and whether fluoxetine or ketamine inhibits such depressive-like behaviors. Here, in rats, we used 192 IgG-saporin to eliminate the cholinergic neurons of the HDB and evaluated depressive-like behaviors using a preference test for sucrose solution and the forced swimming test. Fourteen days after the injection of 192 IgG-saporin into the HDB, the rats exhibited a significantly fewer number of choline acetyltransferase positive cell density in HDB, accompanied with neuronal loss in the entir"],"journal":["Frontiers in behavioral neuroscience"],"pagination":["602708"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7930217"],"repository":["biostudies-literature"],"pubmed_title":["Fluoxetine and Ketamine Reverse the Depressive but Not Anxiety Behavior Induced by Lesion of Cholinergic Neurons in the Horizontal Limb of the Diagonal Band of Broca in Male Rat."],"pmcid":["PMC7930217"],"pubmed_authors":["Ke Y","Liu H","Zhang F","Chen L","Gao L","Ma H","Zhu H","Zhou W","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Fluoxetine and Ketamine Reverse the Depressive but Not Anxiety Behavior Induced by Lesion of Cholinergic Neurons in the Horizontal Limb of the Diagonal Band of Broca in Male Rat.","description":"The basal forebrain cholinergic system is involved in cognitive processes, but the role of the basal forebrain cholinergic system in depression is unknown. We investigated whether a lesion of cholinergic neurons in the horizontal limb of the diagonal band of Broca (HDB) produces depressive-like behavior and whether fluoxetine or ketamine inhibits such depressive-like behaviors. Here, in rats, we used 192 IgG-saporin to eliminate the cholinergic neurons of the HDB and evaluated depressive-like behaviors using a preference test for sucrose solution and the forced swimming test. Fourteen days after the injection of 192 IgG-saporin into the HDB, the rats exhibited a significantly fewer number of choline acetyltransferase positive cell density in HDB, accompanied with neuronal loss in the entir","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-22T10:51:02.921Z","creation":"2021-03-12T08:19:10Z"},"accession":"S-EPMC7930217","cross_references":{"pubmed":["33679340"],"doi":["10.3389/fnbeh.2021.602708"]}}