{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin TY"],"funding":["Ministry of Science and Technology, Taiwan","Taipei Tzu Chi Hospital"],"pagination":["20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7930281"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and An"],"journal":["NPJ biofilms and microbiomes"],"pubmed_title":["Gut dysbiosis and mortality in hemodialysis patients."],"pmcid":["PMC7930281"],"funding_grant_id":["MOST 108-2314-B-303-004-MY3","MOST 105-2314-B-303-014-MY3","MOST 108-2314-B-303-002-MY3","TCAS-108-02","MOST 107-2314-B-303-021"],"pubmed_authors":["Lin YT","Wu PH","Lin TY","Hung SC"],"additional_accession":[]},"is_claimable":false,"name":"Gut dysbiosis and mortality in hemodialysis patients.","description":"Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and An","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-22T08:20:45.232Z","creation":"2025-04-05T22:30:16.556Z"},"accession":"S-EPMC7930281","cross_references":{"pubmed":["33658514"],"doi":["10.1038/s41522-021-00191-x"]}}