{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["58(4)"],"submitter":["Krupska O"],"funding":["Mossakowski Medical Research Centre PAS"],"pubmed_abstract":["The gerbil is a well-known model for studying cerebral ischemia. The CA1 of the hippocampus is vulnerable to 5 min of ischemia, while the CA2-4 and dentate gyrus (DG) are resistant to it. Short-lasting ischemia, a model of transient ischemic attacks in men, results in CA1 neuron death within 2-4 days of reperfusion. Untargeted metabolomics, using LC-QTOF-MS, was used to enrich the knowledge about intrinsic vulnerability and resistance of hippocampal regions and their early post-ischemic response (IR). In total, 30 significant metabolites were detected. In controls, taurine was significantly lower and guanosine monophosphate was higher in CA1, as compared to that in CA2-4,DG. LysoPG and LysoPE were more abundant in CA1, while LysoPI 18:0 was detected only in CA2-4,DG. After IR, a substantia"],"journal":["Molecular neurobiology"],"pagination":["1621-1633"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7932963"],"repository":["biostudies-literature"],"pubmed_title":["Hippocampal Sector-Specific Metabolic Profiles Reflect Endogenous Strategy for Ischemia-Reperfusion Insult Resistance."],"pmcid":["PMC7932963"],"pubmed_authors":["Kowalczyk T","Ciborowski M","Krupska O","Beresewicz-Haller M","Samczuk P","Kretowski A","Zablocki K","Zablocka B","Pietrowska K"],"additional_accession":[]},"is_claimable":false,"name":"Hippocampal Sector-Specific Metabolic Profiles Reflect Endogenous Strategy for Ischemia-Reperfusion Insult Resistance.","description":"The gerbil is a well-known model for studying cerebral ischemia. The CA1 of the hippocampus is vulnerable to 5 min of ischemia, while the CA2-4 and dentate gyrus (DG) are resistant to it. Short-lasting ischemia, a model of transient ischemic attacks in men, results in CA1 neuron death within 2-4 days of reperfusion. Untargeted metabolomics, using LC-QTOF-MS, was used to enrich the knowledge about intrinsic vulnerability and resistance of hippocampal regions and their early post-ischemic response (IR). In total, 30 significant metabolites were detected. In controls, taurine was significantly lower and guanosine monophosphate was higher in CA1, as compared to that in CA2-4,DG. LysoPG and LysoPE were more abundant in CA1, while LysoPI 18:0 was detected only in CA2-4,DG. After IR, a substantia","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-07-16T03:40:46.669Z","creation":"2025-04-05T13:48:38.576Z"},"accession":"S-EPMC7932963","cross_references":{"pubmed":["33222147"],"doi":["10.1007/s12035-020-02208-6"]}}