{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Niziol J"],"funding":["The National Science Foundation","NCRR NIH HHS","Narodowe Centrum Nauki","National Institutes of Health","M.J. Murdock Charitable Trust"],"pagination":["30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7932981"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["<h4>Introduction</h4>Kidney cancer is one of the most frequently diagnosed and the most lethal urinary cancer. Despite advances in treatment, no specific biomarker is currently in use to guide therapeutic interventions.<h4>Objectives</h4>Major aim of this work was to perform metabolomic and elemental profiling of human kidney cancer and normal tissue and to evaluate cancer biomarkers.<h4>Methods</h4>Metabolic and elemental profiling of tumor and adjacent normal human kidney tissue from 50 patients with kidney cancer was undertaken using three different analytical methods.<h4>Results</h4>Five potential tissue biomarkers of kidney cancer were identified and quantified using with high-resolution nuclear magnetic resonance spectroscopy. The contents of selected chemical elements in tissues was"],"journal":["Metabolomics : Official journal of the Metabolomic Society"],"pubmed_title":["Metabolomic and elemental profiling of human tissue in kidney cancer."],"pmcid":["PMC7932981"],"funding_grant_id":["2015066:MNL","S10 RR026659","1S10RR13878","NSF-MRI:DBI-1532078","1S10RR026659","2016/23/B/ST4/00062."],"pubmed_authors":["Copie V","Nogueira KOPC","Tripet BP","Arendowski A","Niziol J","Ruman T","Nogueira LB","Ossolinski K"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic and elemental profiling of human tissue in kidney cancer.","description":"<h4>Introduction</h4>Kidney cancer is one of the most frequently diagnosed and the most lethal urinary cancer. Despite advances in treatment, no specific biomarker is currently in use to guide therapeutic interventions.<h4>Objectives</h4>Major aim of this work was to perform metabolomic and elemental profiling of human kidney cancer and normal tissue and to evaluate cancer biomarkers.<h4>Methods</h4>Metabolic and elemental profiling of tumor and adjacent normal human kidney tissue from 50 patients with kidney cancer was undertaken using three different analytical methods.<h4>Results</h4>Five potential tissue biomarkers of kidney cancer were identified and quantified using with high-resolution nuclear magnetic resonance spectroscopy. The contents of selected chemical elements in tissues was","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-07-16T03:40:17.62Z","creation":"2025-04-05T22:31:17.053Z"},"accession":"S-EPMC7932981","cross_references":{"pubmed":["33661419"],"doi":["10.1007/s11306-021-01779-2"]}}