biostudies-literatureNiziol JThe National Science FoundationNCRR NIH HHSNarodowe Centrum NaukiNational Institutes of HealthM.J. Murdock Charitable Trust30https://www.ebi.ac.uk/biostudies/studies/S-EPMC7932981biostudies-literatureUnknown17(3)<h4>Introduction</h4>Kidney cancer is one of the most frequently diagnosed and the most lethal urinary cancer. Despite advances in treatment, no specific biomarker is currently in use to guide therapeutic interventions.<h4>Objectives</h4>Major aim of this work was to perform metabolomic and elemental profiling of human kidney cancer and normal tissue and to evaluate cancer biomarkers.<h4>Methods</h4>Metabolic and elemental profiling of tumor and adjacent normal human kidney tissue from 50 patients with kidney cancer was undertaken using three different analytical methods.<h4>Results</h4>Five potential tissue biomarkers of kidney cancer were identified and quantified using with high-resolution nuclear magnetic resonance spectroscopy. The contents of selected chemical elements in tissues wasMetabolomics : Official journal of the Metabolomic SocietyMetabolomic and elemental profiling of human tissue in kidney cancer.PMC79329812015066:MNLS10 RR0266591S10RR13878NSF-MRI:DBI-15320781S10RR0266592016/23/B/ST4/00062.Copie VNogueira KOPCTripet BPArendowski ANiziol JRuman TNogueira LBOssolinski KfalseMetabolomic and elemental profiling of human tissue in kidney cancer.<h4>Introduction</h4>Kidney cancer is one of the most frequently diagnosed and the most lethal urinary cancer. Despite advances in treatment, no specific biomarker is currently in use to guide therapeutic interventions.<h4>Objectives</h4>Major aim of this work was to perform metabolomic and elemental profiling of human kidney cancer and normal tissue and to evaluate cancer biomarkers.<h4>Methods</h4>Metabolic and elemental profiling of tumor and adjacent normal human kidney tissue from 50 patients with kidney cancer was undertaken using three different analytical methods.<h4>Results</h4>Five potential tissue biomarkers of kidney cancer were identified and quantified using with high-resolution nuclear magnetic resonance spectroscopy. The contents of selected chemical elements in tissues was2021-01-01T00:00:00Z2021 Mar2026-07-16T03:40:17.62Z2025-04-05T22:31:17.053ZS-EPMC79329813366141910.1007/s11306-021-01779-2