{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaw TI"],"funding":["NCI NIH HHS","NIH","NIGMS NIH HHS"],"pagination":["5154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7933146"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of > 200 T-ALL transcriptomes linked USP7 haploinsufficiency with decreased activities of E-proteins. E-proteins are also negatively regulated by TAL1, leading to concerted down-regulation of E-protein target genes involved in T-cell development. In T-ALL cell lines, we showed the physical interaction of USP7 with E-proteins and TAL1 by mass spectrometry and ChIP-seq. Haploinsufficient but not complete CRISPR knock-out of USP7 showed accelerated cell growth and validated transcriptional down-regulation of E-prote"],"journal":["Scientific reports"],"pubmed_title":["Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)."],"pmcid":["PMC7933146"],"funding_grant_id":["R01 GM134382","R01 CA216391","1R01CA216391-01A1","R35 CA210064"],"pubmed_authors":["Shaw TI","Cheng C","Tian L","Look AT","Qian C","Kavdia K","Zhang J","Pagala VR","Easton J","Gu W","Ma X","Dong L","Choi J","Porter SN","Yu J","Ju B","Pei D","Liu Y","Pruett-Miller SM","High A","Janke LJ","Downing JR","Shaner B","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).","description":"USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of > 200 T-ALL transcriptomes linked USP7 haploinsufficiency with decreased activities of E-proteins. E-proteins are also negatively regulated by TAL1, leading to concerted down-regulation of E-protein target genes involved in T-cell development. In T-ALL cell lines, we showed the physical interaction of USP7 with E-proteins and TAL1 by mass spectrometry and ChIP-seq. Haploinsufficient but not complete CRISPR knock-out of USP7 showed accelerated cell growth and validated transcriptional down-regulation of E-prote","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-03T08:53:16.089Z","creation":"2021-03-09T08:17:39Z"},"accession":"S-EPMC7933146","cross_references":{"pubmed":["33664368"],"doi":["10.1038/s41598-021-84647-2"]}}