{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang PP"],"funding":["National Key R&amp;D Program of China","National Key R&D Program of China","National New Drug Innovation Major Project","National Natural Science Foundation of China"],"pagination":["81-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7933302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Four new limonoids, toonayunnanaes F - I (1 - 4), and six known compounds (5 - 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC<sub>50</sub> 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages."],"journal":["Natural products and bioprospecting"],"pubmed_title":["Four New Limonoids from the Barks of Toona ciliata."],"pmcid":["PMC7933302"],"funding_grant_id":["2018YFC1707105","31470416","2018ZX09711-001-007"],"pubmed_authors":["Zhang PP","Cui ZR","Xue S","Luo J","Kong LY","Bu YG","Tang PF"],"additional_accession":[]},"is_claimable":false,"name":"Four New Limonoids from the Barks of Toona ciliata.","description":"Four new limonoids, toonayunnanaes F - I (1 - 4), and six known compounds (5 - 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC<sub>50</sub> 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-22T08:20:06.82Z","creation":"2025-04-05T22:29:45.709Z"},"accession":"S-EPMC7933302","cross_references":{"pubmed":["33098068"],"doi":["10.1007/s13659-020-00274-w"]}}