biostudies-literatureZhang PPNational Key R&D Program of ChinaNational Key R&D Program of ChinaNational New Drug Innovation Major ProjectNational Natural Science Foundation of China81-86https://www.ebi.ac.uk/biostudies/studies/S-EPMC7933302biostudies-literatureUnknown11(1)Four new limonoids, toonayunnanaes F - I (1 - 4), and six known compounds (5 - 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC₅₀ 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.Natural products and bioprospectingFour New Limonoids from the Barks of Toona ciliata.PMC79333022018YFC1707105314704162018ZX09711-001-007Zhang PPCui ZRXue SLuo JKong LYBu YGTang PFfalseFour New Limonoids from the Barks of Toona ciliata.Four new limonoids, toonayunnanaes F - I (1 - 4), and six known compounds (5 - 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC₅₀ 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.2021-01-01T00:00:00Z2021 Feb2025-04-22T08:20:06.82Z2025-04-05T22:29:45.709ZS-EPMC79333023309806810.1007/s13659-020-00274-w