biostudies-literatureQi YMedical Science Advancement Program (Basic Medical Sciences) of Wuhan UniversityNational Key Research and Development Program of China Stem Cell and Translational ResearchMajor Technological Innovation Projects of Hubei ProvinceNational Natural Science Foundation of ChinaProgram of Excellent Doctoral (Postdoctoral) of Zhongnan Hospital of Wuhan UniversityZhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund Project163https://www.ebi.ac.uk/biostudies/studies/S-EPMC7934528biostudies-literatureUnknown12(1)<h4>Background</h4>Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) could be programmable to "remember" early-life stimuli. Here, we aimed to explore an early-warning biomarker of fetal-originated adult osteoarthritis in the WJ-MSCs.<h4>Methods</h4>Firstly, two kinds of WJ-MSCs were applied to evaluate their chondrogenic potential in vitro through inducing chondrogenic differentiation as the first step of our strategy, one from newborns with IUGR and the other from normal newborns but treated with excessive cortisol during differentiation to simulate the excessive maternal glucocorticoid in the IUGR newStem cell research & therapyH3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy.PMC7934528TFJC2018001ZNYB20190122019ACA140, 2020BCA071znpy20170112020YFA080390081673490, 81972036, 82030111Wen YYang XHe ZMagdalou JQi YChen LLi BWang HChen BZhao ZfalseH3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy.<h4>Background</h4>Epidemiological investigation and our previous reports indicated that osteoarthritis had a fetal origin and was closely associated with intrauterine growth retardation (IUGR). Human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) could be programmable to "remember" early-life stimuli. Here, we aimed to explore an early-warning biomarker of fetal-originated adult osteoarthritis in the WJ-MSCs.<h4>Methods</h4>Firstly, two kinds of WJ-MSCs were applied to evaluate their chondrogenic potential in vitro through inducing chondrogenic differentiation as the first step of our strategy, one from newborns with IUGR and the other from normal newborns but treated with excessive cortisol during differentiation to simulate the excessive maternal glucocorticoid in the IUGR new2021-01-01T00:00:00Z2021 Mar2025-04-04T09:55:40.664Z2021-03-12T08:18:12ZS-EPMC79345283366360910.1186/s13287-021-02234-8