biostudies-literatureFu C"Financial Support for Selected Researchers Back from Abroad (2012)" from Liaoning Province1011-1025https://www.ebi.ac.uk/biostudies/studies/S-EPMC7935791biostudies-literatureUnknown112(3)Myeloid-derived suppressor cells (MDSCs) are responsible for antitumor immunodeficiency in tumor-bearing hosts. Primarily, MDSCs are classified into 2 groups: monocytic (M)-MDSCs and polymorphonuclear (PMN)-MDSCs. In most cancers, PMN-MDSCs (CD11b⁺ Ly6C^low Ly6G⁺ cells) represent the most abundant MDSC subpopulation. However, the functional and phenotypic heterogeneities of PMN-MDSC remain elusive, which delays clinical therapeutic targeting decisions. In the 4T1 murine tumor model, CD11b⁺ Ly6G^low PMN-MDSCs were sensitive to surgical and pharmacological interventions. By comprehensively analyzing 64 myeloid cell-related surface molecule expression profiles, cell density, nuclear morphology, and immunosuppressive activity, the PMN-MDSC pCancer scienceCD205⁺ polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.PMC793579188030312004Zheng KFu CMa SGu XZhang YFu ZTang SZhou DJiang CXia CLyu SfalseCD205⁺ polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3.Myeloid-derived suppressor cells (MDSCs) are responsible for antitumor immunodeficiency in tumor-bearing hosts. Primarily, MDSCs are classified into 2 groups: monocytic (M)-MDSCs and polymorphonuclear (PMN)-MDSCs. In most cancers, PMN-MDSCs (CD11b⁺ Ly6C^low Ly6G⁺ cells) represent the most abundant MDSC subpopulation. However, the functional and phenotypic heterogeneities of PMN-MDSC remain elusive, which delays clinical therapeutic targeting decisions. In the 4T1 murine tumor model, CD11b⁺ Ly6G^low PMN-MDSCs were sensitive to surgical and pharmacological interventions. By comprehensively analyzing 64 myeloid cell-related surface molecule expression profiles, cell density, nuclear morphology, and immunosuppressive activity, the PMN-MDSC p2021-01-01T00:00:00Z2021 Mar2025-04-04T18:37:22.527Z2025-04-04T18:37:22.527ZS-EPMC79357913336888310.1111/cas.14783