{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Senmatsu S"],"funding":["MEXT | Japan Society for the Promotion of Science","Takeda Science Foundation","Yamada Science Foundation"],"pagination":["295"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7935937"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(1)"],"pubmed_abstract":["Noncoding RNAs (ncRNAs) are involved in various biological processes, including gene expression, development, and disease. Here, we identify a novel consensus sequence of a cis-element involved in long ncRNA (lncRNA) transcription and demonstrate that lncRNA transcription from this cis-element activates meiotic recombination via chromatin remodeling. In the fission yeast fbp1 gene, glucose starvation induces a series of promoter-associated lncRNAs, referred to as metabolic-stress-induced lncRNAs (mlonRNAs), which contribute to chromatin remodeling and fbp1 activation. Translocation of the cis-element required for mlonRNA into a well-characterized meiotic recombination hotspot, ade6-M26, further stimulates transcription and meiotic recombination via local chromatin remodeling. The consensus sequence of this cis-element (mlon-box) overlaps with meiotic recombination sites in the fission yeast genome. At one such site, the SPBC24C6.09c upstream region, meiotic double-strand break (DSB) formation is induced in an mlon-box-dependent manner. Therefore, mlonRNA transcription plays a universal role in chromatin remodeling and the regulation of transcription and recombination."],"journal":["Communications biology"],"pubmed_title":["lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast."],"pmcid":["PMC7935937"],"funding_grant_id":["KAKENHIJP16H01314","KAKENHIJP19J20773"],"pubmed_authors":["Oda A","Asada R","Hirota K","Hoffman CS","Senmatsu S","Ohta K"],"additional_accession":[]},"is_claimable":false,"name":"lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast.","description":"Noncoding RNAs (ncRNAs) are involved in various biological processes, including gene expression, development, and disease. Here, we identify a novel consensus sequence of a cis-element involved in long ncRNA (lncRNA) transcription and demonstrate that lncRNA transcription from this cis-element activates meiotic recombination via chromatin remodeling. In the fission yeast fbp1 gene, glucose starvation induces a series of promoter-associated lncRNAs, referred to as metabolic-stress-induced lncRNAs (mlonRNAs), which contribute to chromatin remodeling and fbp1 activation. Translocation of the cis-element required for mlonRNA into a well-characterized meiotic recombination hotspot, ade6-M26, further stimulates transcription and meiotic recombination via local chromatin remodeling. The consensus sequence of this cis-element (mlon-box) overlaps with meiotic recombination sites in the fission yeast genome. At one such site, the SPBC24C6.09c upstream region, meiotic double-strand break (DSB) formation is induced in an mlon-box-dependent manner. Therefore, mlonRNA transcription plays a universal role in chromatin remodeling and the regulation of transcription and recombination.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T13:29:00.4Z","creation":"2025-04-06T23:16:04.855Z"},"accession":"S-EPMC7935937","cross_references":{"pubmed":["33674718"],"doi":["10.1038/s42003-021-01798-8"]}}