{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cheng S"],"funding":["Natural Science Foundation of Jiangxi Province","National Natural Science Foundation of China"],"pagination":["100877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7936122"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["100(3)"],"pubmed_abstract":["Broiler ascites syndrome (AS), also called pulmonary artery hypertension, is a metabolic disorder that has been observed worldwide in fast-growing broilers. Pulmonary arterial remodeling is a key step in the development of AS. The precise relationship between mRNA and SNP of the pulmonary artery in regulating AS progression remains unclear. In this study, we obtained pulmonary artery tissues from broilers with AS to perform pathologic section and pathologic anatomic observation. SNP, InDel, and mRNA data analysis were carried out using GATK and ANNOVAR software to study the SNP loci of 985 previously reported genes (437 upregulated and 458 downregulated). The pathology results showed that there was a lot of yellow fluid in the abdominal cavity and pericardium, that the ascites cardiac inde"],"journal":["Poultry science"],"pubmed_title":["Dysregulated expression of mRNA and SNP in pulmonary artery remodeling in ascites syndrome in broilers."],"pmcid":["PMC7936122"],"funding_grant_id":["20171ACB21026","31960723","GJJ191400","GJJ170243","31402266"],"pubmed_authors":["Li G","Jiang J","Zhou Q","Guo X","Huang H","Liu P","Wu C","Li L","Cheng S","Liu X","Hu G","Ping Liu","Luo S","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated expression of mRNA and SNP in pulmonary artery remodeling in ascites syndrome in broilers.","description":"Broiler ascites syndrome (AS), also called pulmonary artery hypertension, is a metabolic disorder that has been observed worldwide in fast-growing broilers. Pulmonary arterial remodeling is a key step in the development of AS. The precise relationship between mRNA and SNP of the pulmonary artery in regulating AS progression remains unclear. In this study, we obtained pulmonary artery tissues from broilers with AS to perform pathologic section and pathologic anatomic observation. SNP, InDel, and mRNA data analysis were carried out using GATK and ANNOVAR software to study the SNP loci of 985 previously reported genes (437 upregulated and 458 downregulated). The pathology results showed that there was a lot of yellow fluid in the abdominal cavity and pericardium, that the ascites cardiac inde","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T11:37:25.466Z","creation":"2024-11-13T16:15:04.631Z"},"accession":"S-EPMC7936122","cross_references":{"pubmed":["33518352"],"doi":["10.1016/j.psj.2020.11.054"]}}