{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin L"],"funding":["National Natural Science Foundation of China"],"pagination":["628-642"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7936294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["As a pathogenic fungus, Aspergillus flavus can produce carcinogenic aflatoxins (AFs), which poses a great threat to crops and animals. Msb2, the signalling mucin protein, is a part of mitogen-activated protein kinase (MAPK) pathway which contributes to a range of physiological processes. In this study, the roles of membrane mucin Msb2 were explored in A. flavus by the application of gene disruption. The deletion of msb2 gene (Δmsb2) caused defects in vegetative growth, sporulation and sclerotia formation when compared to WT and complement strain (Δmsb2<sup>C</sup> ) in A. flavus. Using thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis, it was found that deletion of msb2 down-regulated aflatoxin B<sub>1</sub> (AFB<sub>1</sub> ) synthesis and decrease"],"journal":["Microbial biotechnology"],"pubmed_title":["The membrane mucin Msb2 regulates aflatoxin biosynthesis and pathogenicity in fungus Aspergillus flavus."],"pmcid":["PMC7936294"],"funding_grant_id":["31600118","31772105，"],"pubmed_authors":["Yang G","Qin L","Li D","Yang K","Wang S","Tumukunde E","Wang Y","Zhao J","Yuan J"],"additional_accession":[]},"is_claimable":false,"name":"The membrane mucin Msb2 regulates aflatoxin biosynthesis and pathogenicity in fungus Aspergillus flavus.","description":"As a pathogenic fungus, Aspergillus flavus can produce carcinogenic aflatoxins (AFs), which poses a great threat to crops and animals. Msb2, the signalling mucin protein, is a part of mitogen-activated protein kinase (MAPK) pathway which contributes to a range of physiological processes. In this study, the roles of membrane mucin Msb2 were explored in A. flavus by the application of gene disruption. The deletion of msb2 gene (Δmsb2) caused defects in vegetative growth, sporulation and sclerotia formation when compared to WT and complement strain (Δmsb2<sup>C</sup> ) in A. flavus. Using thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis, it was found that deletion of msb2 down-regulated aflatoxin B<sub>1</sub> (AFB<sub>1</sub> ) synthesis and decrease","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-03T21:32:19.14Z","creation":"2025-04-03T21:32:19.14Z"},"accession":"S-EPMC7936294","cross_references":{"pubmed":["33159717"],"doi":["10.1111/1751-7915.13701"]}}