{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(3)"],"submitter":["Krassikova L"],"funding":["Vetenskapsrådet","Cancerfonden"],"pubmed_abstract":["Cancer cells undergo complex metabolic alterations. The mechanisms underlying the tuning of cancer metabolism are under active investigation. Here, we identify the uncharacterized deubiquitinase JOSD2 as a positive regulator of cancer cell proliferation by displaying comprehensive effects on glucose catabolism. We found that JOSD2 directly controls a metabolic enzyme complex that includes Aldolase A, Phosphofructokinase-1 and Phosphoglycerate dehydrogenase, in vitro and in vivo. Further, JOSD2 expression, but not a catalytically inactive mutant, deubiquitinates and stabilizes the enzyme complex, thereby enhancing their activities and the glycolytic rate. This represents a selective JOSD2 feature that is not shared among other Machado-Joseph disease DUBs or observed in nontransformed cells."],"journal":["Cell death and differentiation"],"pagination":["1091-1109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7937685"],"repository":["biostudies-literature"],"pubmed_title":["The deubiquitinase JOSD2 is a positive regulator of glucose metabolism."],"pmcid":["PMC7937685"],"pubmed_authors":["Nagarajan D","Queiroz AL","Samakidis E","Vakifahmetoglu-Norberg H","Norberg E","Zhang B","Krassikova L","Kacal M"],"additional_accession":[]},"is_claimable":false,"name":"The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.","description":"Cancer cells undergo complex metabolic alterations. The mechanisms underlying the tuning of cancer metabolism are under active investigation. Here, we identify the uncharacterized deubiquitinase JOSD2 as a positive regulator of cancer cell proliferation by displaying comprehensive effects on glucose catabolism. We found that JOSD2 directly controls a metabolic enzyme complex that includes Aldolase A, Phosphofructokinase-1 and Phosphoglycerate dehydrogenase, in vitro and in vivo. Further, JOSD2 expression, but not a catalytically inactive mutant, deubiquitinates and stabilizes the enzyme complex, thereby enhancing their activities and the glycolytic rate. This represents a selective JOSD2 feature that is not shared among other Machado-Joseph disease DUBs or observed in nontransformed cells.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-04-08T17:57:56.907Z","creation":"2025-04-05T22:21:33.806Z"},"accession":"S-EPMC7937685","cross_references":{"pubmed":["33082514"],"doi":["10.1038/s41418-020-00639-1"]}}