{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["65"],"submitter":["Mao D"],"funding":["The Chinese University of Hong Kong"],"pubmed_abstract":["<h4>Background</h4>Type 2 diabetes (T2D) increases the risk of many types of cancer. Dysregulation of proteasome-related protein degradation leads to tumorigenesis, while Exendin-4, a glucagon-like peptide 1 receptor (GLP-1R) agonist, possesses anti-cancer effects.<h4>Methods</h4>We explored the co-expression of proteasome alpha 2 subunit (PSMA2) and GLP-1R in the Cancer Genome Atlas (TCGA) database and human cervical cancer specimens, supplemented by in vivo and in vitro studies using multiple cervical cancer cell lines.<h4>Findings</h4>PSMA2 expression was increased in 12 cancer types in TCGA database and cervical cancer specimens from patients with T2D (T2D vs non-T2D: 3.22 (95% confidence interval CI: 1.38, 5.05) vs 1.00 (0.66, 1.34) fold change, P = 0.01). psma2-shRNA decreased cell p"],"journal":["EBioMedicine"],"pagination":["103242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7938253"],"repository":["biostudies-literature"],"pubmed_title":["Increased co-expression of PSMA2 and GLP-1 receptor in cervical cancer models in type 2 diabetes attenuated by Exendin-4: A translational case-control study."],"pmcid":["PMC7938253"],"pubmed_authors":["Lui VWY","Shi M","Cao H","Hou Y","Ming X","Chow E","Chan PKS","Li JJX","Wong CK","Lee HM","Mao D","Kwong J","Kong APS","Wang CC","Chan JCN","Tian XY"],"additional_accession":[]},"is_claimable":false,"name":"Increased co-expression of PSMA2 and GLP-1 receptor in cervical cancer models in type 2 diabetes attenuated by Exendin-4: A translational case-control study.","description":"<h4>Background</h4>Type 2 diabetes (T2D) increases the risk of many types of cancer. Dysregulation of proteasome-related protein degradation leads to tumorigenesis, while Exendin-4, a glucagon-like peptide 1 receptor (GLP-1R) agonist, possesses anti-cancer effects.<h4>Methods</h4>We explored the co-expression of proteasome alpha 2 subunit (PSMA2) and GLP-1R in the Cancer Genome Atlas (TCGA) database and human cervical cancer specimens, supplemented by in vivo and in vitro studies using multiple cervical cancer cell lines.<h4>Findings</h4>PSMA2 expression was increased in 12 cancer types in TCGA database and cervical cancer specimens from patients with T2D (T2D vs non-T2D: 3.22 (95% confidence interval CI: 1.38, 5.05) vs 1.00 (0.66, 1.34) fold change, P = 0.01). psma2-shRNA decreased cell p","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-04-30T17:20:14.708Z","creation":"2022-02-10T08:52:00.856Z"},"accession":"S-EPMC7938253","cross_references":{"pubmed":["33684886"],"doi":["10.1016/j.ebiom.2021.103242"]}}