{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ito T"],"funding":["Japan Society for the Promotion of Science"],"pagination":["95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7938685"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Endothelial cells play a key role in maintaining intravascular patency through their anticoagulant properties. They provide a favorable environment for plasma anticoagulant proteins, including antithrombin, tissue factor pathway inhibitor, and protein C. Under septic conditions, however, the anticoagulant properties of endothelial cells are compromised. Rather, activated/injured endothelial cells can provide a scaffold for intravascular coagulation. For example, the expression of tissue factor, an important initiator of the coagulation pathway, is induced on the surface of activated endothelial cells. Phosphatidylserine, a high-affinity scaffold for gamma-carboxyglutamate domain containing coagulation factors, including FII, FVII, FIX, and FX, is externalized to the outer leaflet of the pl"],"journal":["Critical care (London, England)"],"pubmed_title":["Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation."],"pmcid":["PMC7938685"],"funding_grant_id":["Grants-in-Aid 18H02904"],"pubmed_authors":["Ito T","Maruyama I","Kakuuchi M"],"additional_accession":[]},"is_claimable":false,"name":"Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation.","description":"Endothelial cells play a key role in maintaining intravascular patency through their anticoagulant properties. They provide a favorable environment for plasma anticoagulant proteins, including antithrombin, tissue factor pathway inhibitor, and protein C. Under septic conditions, however, the anticoagulant properties of endothelial cells are compromised. Rather, activated/injured endothelial cells can provide a scaffold for intravascular coagulation. For example, the expression of tissue factor, an important initiator of the coagulation pathway, is induced on the surface of activated endothelial cells. Phosphatidylserine, a high-affinity scaffold for gamma-carboxyglutamate domain containing coagulation factors, including FII, FVII, FIX, and FX, is externalized to the outer leaflet of the pl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-21T19:40:53.427Z","creation":"2021-03-13T08:18:24Z"},"accession":"S-EPMC7938685","cross_references":{"pubmed":["33685461"],"doi":["10.1186/s13054-021-03524-6"]}}