biostudies-literatureIto TJapan Society for the Promotion of Science95https://www.ebi.ac.uk/biostudies/studies/S-EPMC7938685biostudies-literatureUnknown25(1)Endothelial cells play a key role in maintaining intravascular patency through their anticoagulant properties. They provide a favorable environment for plasma anticoagulant proteins, including antithrombin, tissue factor pathway inhibitor, and protein C. Under septic conditions, however, the anticoagulant properties of endothelial cells are compromised. Rather, activated/injured endothelial cells can provide a scaffold for intravascular coagulation. For example, the expression of tissue factor, an important initiator of the coagulation pathway, is induced on the surface of activated endothelial cells. Phosphatidylserine, a high-affinity scaffold for gamma-carboxyglutamate domain containing coagulation factors, including FII, FVII, FIX, and FX, is externalized to the outer leaflet of the plCritical care (London, England)Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation.PMC7938685Grants-in-Aid 18H02904Ito TMaruyama IKakuuchi MfalseEndotheliopathy in septic conditions: mechanistic insight into intravascular coagulation.Endothelial cells play a key role in maintaining intravascular patency through their anticoagulant properties. They provide a favorable environment for plasma anticoagulant proteins, including antithrombin, tissue factor pathway inhibitor, and protein C. Under septic conditions, however, the anticoagulant properties of endothelial cells are compromised. Rather, activated/injured endothelial cells can provide a scaffold for intravascular coagulation. For example, the expression of tissue factor, an important initiator of the coagulation pathway, is induced on the surface of activated endothelial cells. Phosphatidylserine, a high-affinity scaffold for gamma-carboxyglutamate domain containing coagulation factors, including FII, FVII, FIX, and FX, is externalized to the outer leaflet of the pl2021-01-01T00:00:00Z2021 Mar2025-04-21T19:40:53.427Z2021-03-13T08:18:24ZS-EPMC79386853368546110.1186/s13054-021-03524-6