{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["47(4)"],"submitter":["Shehabi Y"],"funding":["National Health and Medical Research Council"],"pubmed_abstract":["<h4>Purpose</h4>To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and identify patients who have a high probability of lower or higher 90-day mortality according to age, and other identified clusters.<h4>Methods</h4>Bayesian analysis of 3904 critically ill adult patients expected to receive invasive ventilation > 24 h and enrolled in a multinational randomized controlled trial comparing early DEX with usual care sedation.<h4>Results</h4>HTE was assessed according to age and clusters (based on 12 baseline characteristics) using a Bayesian hierarchical models. DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible interval [CrI] 0.68-1"],"journal":["Intensive care medicine"],"pagination":["455-466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7939103"],"repository":["biostudies-literature"],"pubmed_title":["Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial."],"pmcid":["PMC7939103"],"pubmed_authors":["Paterson R","Dias A","Tonks A","Hassan MA","Hassan MH","Macallum N","Ferrier J","Mamo D","McArthur C","Comadira G","Liew S","Fletcher J","Webb SA","Macgill S","Al-Dawood A","Akaltan M","Young P","Waddy S","Young H","Colombo S","Bailey M","Berger S","Calder V","Andrew G","Miller K","White M","France D","Elliot S","Waugh V","Bodenham V","Turner E","Vucago AM","McCulloch C","Deeb A","Gresham R","Clarey E","Duroux M","Abudayah A","Maher L","Landoni G","Blakemore A","Maher K","Eastwood G","Peck L","Hasan MS","Tallott M","Voon WL","Naseem N","Serpa Neto A","Judd H","Tamang KL","Lesona E","Tan ITA","Bhatia D","Macklin A","McConnochie R","Snelson C","Asen K","Wetzig K","Ewan J","Arabi YM","Hyde N","Blaser D","Chen Y","Reynolds C","Murray L","Ball J","Rahman RA","Noble H","Ellis K","Samat NM","Noble S","Wehr A","Caba RC","Barge D","Arif A","Lowrey J","Campos S","Walsham J","Shehabi Y","Harkett S","Skelly C","MacNaughton P","Nettelbeck K","Serban C","Blackburn E","Sharpe S","Jordan A","Babio-Galan M","Smyth D","Patrick-Heselton J","Leggieri C","Yarad E","Sulaiman S","Dukes S","Al Saeedi A","Kadiman S","Janin P","Bennett-Britton J","Clatworthy B","Bone A","Phillips M","Gregory R","Edington J","Zabidi IN","Harris A","Lai V","Harris C","Parke R","Martin-Loeches I","Whitehead C","Cooper L","Fourie C","Wan R","Galt P","Carrera R","Edney S","Cooper G","Conlon L","Latimer-Bell C","Jong ML","Boschert C","Al-Harthy AM","Emperan 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F","Hurford S","Corcoran E","Seppelt IM","Azzolini ML","SPICE III Study Investigators","Bold C","Tam K","Squire R","Azmi N","Soar N","Joyce C","Simpson N","Valerio J","Magdi I","Wang A","Hemmings N","Almekhlafi G","Bahar NI","Keating L","Barclay L","Stephens D","Berry W","Minto E","Mucci M","Park M","Al Anizi H","Hope D","Brooks J","Ho J","Mellinghoff J","Beccaria P","Elloway E","Stuart J","Naumoff J","Lim CH","Husin NS","Abdullah NH","Rechnitzer T","Wafer P","Ismail A","Alonso UB","Finney C","Sabran IN","Long S","Stedman W","Zabidi N","Song R","Ismail SZ","Bamford A","Awang R","Morgan C","Whitton C","Campbell L","Jarrett P","Omar SC","Palmer N","Wild L","Cameron R","Morgan M"],"additional_accession":[]},"is_claimable":false,"name":"Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.","description":"<h4>Purpose</h4>To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and identify patients who have a high probability of lower or higher 90-day mortality according to age, and other identified clusters.<h4>Methods</h4>Bayesian analysis of 3904 critically ill adult patients expected to receive invasive ventilation > 24 h and enrolled in a multinational randomized controlled trial comparing early DEX with usual care sedation.<h4>Results</h4>HTE was assessed according to age and clusters (based on 12 baseline characteristics) using a Bayesian hierarchical models. DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible interval [CrI] 0.68-1","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-05-29T22:18:14.534Z","creation":"2025-05-29T22:18:14.534Z"},"accession":"S-EPMC7939103","cross_references":{"pubmed":["33686482"],"doi":["10.1007/s00134-021-06356-8"]}}