{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Niu M"],"funding":["National Key R&D Program of China","National Natural Science Foundation of China"],"pagination":["e3001113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7939357"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(2)"],"pubmed_abstract":["Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program and functions as a critical metastasis suppressor. It has been documented that the expression of ΔNp63α is tightly controlled by oncogenic signaling and is frequently reduced in advanced cancers. However, whether TGF-β signaling regulates ΔNp63α expression in promoting metastasis is largely unclear. In this study, we demonstrate that activation of TGF-β signaling leads to stabilization of E3 ubiquitin ligase FBXO3, which, in turn, targets ΔNp63α for proteasomal degradation in a Smad-indepe"],"journal":["PLoS biology"],"pubmed_title":["Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis."],"pmcid":["PMC7939357"],"funding_grant_id":["2018YFC2000100","82073248","31701242","81520108020, 81830108 and 81861148031"],"pubmed_authors":["He T","Yi Y","He Y","Li F","Xiao ZJ","Niu M","Chen H","Chen YG","Guo R","Fu M","Xu J","Ding L"],"additional_accession":[]},"is_claimable":false,"name":"Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis.","description":"Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program and functions as a critical metastasis suppressor. It has been documented that the expression of ΔNp63α is tightly controlled by oncogenic signaling and is frequently reduced in advanced cancers. However, whether TGF-β signaling regulates ΔNp63α expression in promoting metastasis is largely unclear. In this study, we demonstrate that activation of TGF-β signaling leads to stabilization of E3 ubiquitin ligase FBXO3, which, in turn, targets ΔNp63α for proteasomal degradation in a Smad-indepe","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-07-13T03:04:51.172Z","creation":"2025-07-13T03:04:51.172Z"},"accession":"S-EPMC7939357","cross_references":{"pubmed":["33626035"],"doi":["10.1371/journal.pbio.3001113"]}}