{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tandoh KZ"],"funding":["Wellcome Trust"],"pagination":["1176934321999640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7940735"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17"],"pubmed_abstract":["Sub-Saharan Africa is courting the risk of artemisinin resistance (ARTr) emerging in <i>Plasmodium falciparum</i> malaria parasites. Current molecular surveillance efforts for ARTr have been built on the utility of <i>P. falciparum</i> kelch13 (<i>pfk13</i>) validated molecular markers. However, whether these molecular markers will serve the purpose of early detection of artemisinin-resistant parasites in Ghana is hinged on a <i>pfk13</i> dependent evolution. Here, we tested the hypothesis that the background <i>pfk13</i> genome may be present before the <i>pfk13</i> ARTr-conferring variant(s) is selected and that signatures of balancing selection on these genomic loci may serve as an early warning signal of ARTr. We analyzed 12 198 single nucleotide polymorphisms (SNPs) in Ghanaian clinic"],"journal":["Evolutionary bioinformatics online"],"pubmed_title":["<i>Plasmodium falciparum</i> Malaria Parasites in Ghana Show Signatures of Balancing Selection at Artemisinin Resistance Predisposing Background Genes."],"pmcid":["PMC7940735"],"funding_grant_id":["107755/Z/15/Z"],"pubmed_authors":["Duah-Quashie NO","Quashie NB","Tandoh KZ","Amenga-Etego L","Wilson M","Awandare G"],"additional_accession":[]},"is_claimable":false,"name":"<i>Plasmodium falciparum</i> Malaria Parasites in Ghana Show Signatures of Balancing Selection at Artemisinin Resistance Predisposing Background Genes.","description":"Sub-Saharan Africa is courting the risk of artemisinin resistance (ARTr) emerging in <i>Plasmodium falciparum</i> malaria parasites. Current molecular surveillance efforts for ARTr have been built on the utility of <i>P. falciparum</i> kelch13 (<i>pfk13</i>) validated molecular markers. However, whether these molecular markers will serve the purpose of early detection of artemisinin-resistant parasites in Ghana is hinged on a <i>pfk13</i> dependent evolution. Here, we tested the hypothesis that the background <i>pfk13</i> genome may be present before the <i>pfk13</i> ARTr-conferring variant(s) is selected and that signatures of balancing selection on these genomic loci may serve as an early warning signal of ARTr. We analyzed 12 198 single nucleotide polymorphisms (SNPs) in Ghanaian clinic","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T22:00:39.752Z","creation":"2025-04-04T22:00:39.752Z"},"accession":"S-EPMC7940735","cross_references":{"pubmed":["33746510"],"doi":["10.1177/1176934321999640"]}}