{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(4)"],"submitter":["Wang JT"],"pubmed_abstract":["<h4>Aims</h4>Type 2 diabetes mellitus (T2DM) can lead to brain dysfunction and a series of neurological complications. Previous research demonstrated that a novel palmitic acid (5-PAHSA) exerts effect on glucose tolerance and chronic inflammation. Autophagy was important in diabetic-related neurodegeneration. The aim of the present study was to investigate whether 5-PAHSA has specific therapeutic effects on neurological dysfunction in diabetics, particularly with regard to autophagy.<h4>Methods</h4>5-PAHSA was successfully synthesized according to a previously described protocol. We then carried out a series of in vitro and in vivo experiments using PC12 cells under diabetic conditions, and DB/DB mice, respectively. PC12 cells were treated with 5-PAHSA for 24 h, while mice were administere"],"journal":["CNS neuroscience & therapeutics"],"pagination":["484-496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7941174"],"repository":["biostudies-literature"],"pubmed_title":["A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy."],"pmcid":["PMC7941174"],"pubmed_authors":["Xue JZ","Xu XD","Xue WJ","He CF","Wang JT","Wen XH","Tao YH","Zhang Q","Wang YM","Guo QL","Zhou HG","Guo JC","Yu ZY","Liu YC"],"additional_accession":[]},"is_claimable":false,"name":"A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy.","description":"<h4>Aims</h4>Type 2 diabetes mellitus (T2DM) can lead to brain dysfunction and a series of neurological complications. Previous research demonstrated that a novel palmitic acid (5-PAHSA) exerts effect on glucose tolerance and chronic inflammation. Autophagy was important in diabetic-related neurodegeneration. The aim of the present study was to investigate whether 5-PAHSA has specific therapeutic effects on neurological dysfunction in diabetics, particularly with regard to autophagy.<h4>Methods</h4>5-PAHSA was successfully synthesized according to a previously described protocol. We then carried out a series of in vitro and in vivo experiments using PC12 cells under diabetic conditions, and DB/DB mice, respectively. PC12 cells were treated with 5-PAHSA for 24 h, while mice were administere","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-22T10:48:53.108Z","creation":"2025-04-05T23:39:46.676Z"},"accession":"S-EPMC7941174","cross_references":{"pubmed":["33459523"],"doi":["10.1111/cns.13573"]}}