{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang Q"],"funding":["Open Foundation of Shandong Provincial Key Laboratory of Oral Tissue Regeneration","National Key R&D Program of China","National Natural Science Foundation of China","Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, The National Key Research and Development Program of China","Construction Engineering Special Fund of \"Taishan Scholars\" of Shandong Province"],"pagination":["e12997"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7941242"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(3)"],"pubmed_abstract":["Objectives
Stromal cell-derived factor-1 (SDF-1) actively directs endogenous cell homing. Exendin-4 (EX-4) promotes stem cell osteogenic differentiation. Studies revealed that EX-4 strengthened SDF-1-mediated stem cell migration. However, the effects of SDF-1 and EX-4 on periodontal ligament stem cells (PDLSCs) and bone regeneration have not been investigated. In this study, we aimed to evaluate the effects of SDF-1/EX-4 cotherapy on PDLSCs in vitro and periodontal bone regeneration in vivo.Methods
Cell-counting kit-8 (CCK8), transwell assay, qRT-PCR and western blot were used to determine the effects and mechanism of SDF-1/EX-4 cotherapy on PDLSCs in vitro. A rat periodontal bone defect model was developed to evaluate the effects of topical application of SDF-1 and systemi"],"journal":["Cell proliferation"],"pubmed_title":["Stromal cell-derived factor-1/Exendin-4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo."],"pmcid":["PMC7941242"],"funding_grant_id":["81873716","2017YFA0104604","SDKQ201901","tsqn201909180","SDKQ201904","81670993","2017YFB0405400","ts20190975"],"pubmed_authors":["Ge S","Kang W","Du L","Zhang R","Liang Q"],"additional_accession":[]},"is_claimable":false,"name":"Stromal cell-derived factor-1/Exendin-4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo.","description":"Objectives
Stromal cell-derived factor-1 (SDF-1) actively directs endogenous cell homing. Exendin-4 (EX-4) promotes stem cell osteogenic differentiation. Studies revealed that EX-4 strengthened SDF-1-mediated stem cell migration. However, the effects of SDF-1 and EX-4 on periodontal ligament stem cells (PDLSCs) and bone regeneration have not been investigated. In this study, we aimed to evaluate the effects of SDF-1/EX-4 cotherapy on PDLSCs in vitro and periodontal bone regeneration in vivo.Methods
Cell-counting kit-8 (CCK8), transwell assay, qRT-PCR and western blot were used to determine the effects and mechanism of SDF-1/EX-4 cotherapy on PDLSCs in vitro. A rat periodontal bone defect model was developed to evaluate the effects of topical application of SDF-1 and systemi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T18:58:09.933Z","creation":"2025-04-07T06:43:19.788Z"},"accession":"S-EPMC7941242","cross_references":{"pubmed":["33511708"],"doi":["10.1111/cpr.12997"]}}