biostudies-literatureTang XNational Natural Science Foundation of ChinaThe New Xiangya Talent Project of The Third Xiangya Hospital of Central South University42https://www.ebi.ac.uk/biostudies/studies/S-EPMC7942010biostudies-literatureUnknown19(1)<h4>Background</h4>Endometriosis is a disease that involves active cell invasion and migration. Talin-1 can promote cell invasion, migration and adhension in various cancer cells, but its role in endometriosis has not been investigated. This study was to investigate the expression level of Talin-1 in endometriosis and the role of Talin-1 in the proliferation, adhesion, migration, and invasion of human endometrial stromal cells (ESCs).<h4>Methods</h4>Ectopic and eutopic endometrial tissues were collected from women with endometriosis, and the control endometrial tissues were obtained from patients without endometriosis. The expression level of Talin-1 was detected in each sample using quantitative real-time polymerase chain reaction and immunohistochemistry. The expression of Talin-1 was inReproductive biology and endocrinology : RB&EExpression of Talin-1 in endometriosis and its possible role in pathogenesis.PMC7942010No. JY201706No. 81801422Jiang JLi QLi LTang XfalseExpression of Talin-1 in endometriosis and its possible role in pathogenesis.<h4>Background</h4>Endometriosis is a disease that involves active cell invasion and migration. Talin-1 can promote cell invasion, migration and adhension in various cancer cells, but its role in endometriosis has not been investigated. This study was to investigate the expression level of Talin-1 in endometriosis and the role of Talin-1 in the proliferation, adhesion, migration, and invasion of human endometrial stromal cells (ESCs).<h4>Methods</h4>Ectopic and eutopic endometrial tissues were collected from women with endometriosis, and the control endometrial tissues were obtained from patients without endometriosis. The expression level of Talin-1 was detected in each sample using quantitative real-time polymerase chain reaction and immunohistochemistry. The expression of Talin-1 was in2021-01-01T00:00:00Z2021 Mar2025-04-21T18:11:14.77Z2024-11-12T09:14:41.032ZS-EPMC79420103375040710.1186/s12958-021-00725-0