{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hermans BJM"],"funding":["Netherlands Heart Foundation","Electrophysiological DGK","Theo-Rossi di Montelera (TRM) foundation","Vascular Destabilisation","European Union","Atrial Fibrillation: Interaction between hyperCoagulability","Health Modifiers in the Elderly","AFibTrainNet"],"pagination":["i48-i54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7943360"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(23 Suppl 1)"],"pubmed_abstract":["Aims
We aimed to examine whether routine pulmonary vein isolation (PVI) induces significant ventricular repolarization changes as suggested earlier.Methods and results
Five-minute electrocardiograms were recorded at hospital's admission (T-1d), 1 day after the PVI-procedure (T+1d) and at 3 months post-procedure (T+3m) from a registry of consecutive atrial fibrillation (AF) patients scheduled for routine PVI with different PVI modalities (radiofrequency, cryo-ablation, and hybrid). Only patients who were in sinus rhythm at all three recordings (n = 117) were included. QT-intervals and QT-dispersion were evaluated with custom-made software and QTc was calculated using Bazett's, Fridericia's, Framingham's, and Hodges' formulas. Both QT- and RR-intervals were significantly shorter at T+1d (399 ± 37 and 870 ± 141 ms) and T+3m (407 ± 36 and 950 ± 140 ms) compared with baseline (417 ± 36 and 1025 ± 164 ms). There was no statistically significant within-subject difference in QTc Fridericia (T-1d 416 ± 28 ms, T+1d 419 ± 33 ms, and T+3m 414 ± 25 ms) and QT-dispersion (T-1d 18 ± 12 ms, T+1d 21 ± 19 ms, and T+3m 17 ± 12 ms) between the recordings. A multiple linear regression model with age, sex, AF type, ablation technique, first/re-do ablation, and AF recurrence to predict the change in QTc at T+3m with respect to QTc at T-1d did not reach significance which indicates that the change in QTc does not differ between all subgroups (age, sex, AF type, ablation technique, first/re-do ablation, and AF recurrence).Conclusion
Based on our data a routine PVI does not result in a prolongation of QTc in a real-world population. These findings, therefore, suggest that there is no need to intensify post-PVI QT-interval monitoring."],"journal":["Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology"],"pubmed_title":["Pulmonary vein isolation in a real-world population does not influence QTc interval."],"pmcid":["PMC7943360"],"funding_grant_id":["633196","CVON2014-09","675351"],"pubmed_authors":["Vernooy K","Zink MD","Hermans BJM","van Rosmalen F","Delhaas T","Pison L","Schotten U","Crijns HJGM","Postema P"],"additional_accession":[]},"is_claimable":false,"name":"Pulmonary vein isolation in a real-world population does not influence QTc interval.","description":"Aims
We aimed to examine whether routine pulmonary vein isolation (PVI) induces significant ventricular repolarization changes as suggested earlier.Methods and results
Five-minute electrocardiograms were recorded at hospital's admission (T-1d), 1 day after the PVI-procedure (T+1d) and at 3 months post-procedure (T+3m) from a registry of consecutive atrial fibrillation (AF) patients scheduled for routine PVI with different PVI modalities (radiofrequency, cryo-ablation, and hybrid). Only patients who were in sinus rhythm at all three recordings (n = 117) were included. QT-intervals and QT-dispersion were evaluated with custom-made software and QTc was calculated using Bazett's, Fridericia's, Framingham's, and Hodges' formulas. Both QT- and RR-intervals were significantly shorter at T+1d (399 ± 37 and 870 ± 141 ms) and T+3m (407 ± 36 and 950 ± 140 ms) compared with baseline (417 ± 36 and 1025 ± 164 ms). There was no statistically significant within-subject difference in QTc Fridericia (T-1d 416 ± 28 ms, T+1d 419 ± 33 ms, and T+3m 414 ± 25 ms) and QT-dispersion (T-1d 18 ± 12 ms, T+1d 21 ± 19 ms, and T+3m 17 ± 12 ms) between the recordings. A multiple linear regression model with age, sex, AF type, ablation technique, first/re-do ablation, and AF recurrence to predict the change in QTc at T+3m with respect to QTc at T-1d did not reach significance which indicates that the change in QTc does not differ between all subgroups (age, sex, AF type, ablation technique, first/re-do ablation, and AF recurrence).Conclusion
Based on our data a routine PVI does not result in a prolongation of QTc in a real-world population. These findings, therefore, suggest that there is no need to intensify post-PVI QT-interval monitoring.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2024-02-15T12:15:54.516Z","creation":"2021-03-18T08:36:20Z"},"accession":"S-EPMC7943360","cross_references":{"pubmed":["33751076"],"doi":["10.1093/europace/euaa390"]}}