{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vagts C"],"funding":["NHLBI NIH HHS","National Institutes of Health"],"pagination":["595077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7943443"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["<b>Introduction:</b> Sarcoidosis is a T-helper cell mediated disease characterized by granulomatous inflammation. We posited that unsupervised clustering of various features in sarcoidosis would establish phenotypes associated with inflammatory activity measured by 18FDG-PET/CT. Our goal was to identify unique features capable of distinguishing clusters and subsequently examine the relationship with FDG avidity to substantiate their potential use as markers for sarcoidosis inflammation. <b>Methods:</b> We performed a retrospective study of a diverse, but primarily African American, cohort of 58 subjects with biopsy proven sarcoidosis followed at the University of Illinois Bernie Mac Sarcoidosis Center and Center for Lung Health who underwent 18FDG-PET/CT scan. Demographic, therapeutic, rad"],"journal":["Frontiers in medicine"],"pubmed_title":["Unsupervised Clustering Reveals Sarcoidosis Phenotypes Marked by a Reduction in Lymphocytes Relate to Increased Inflammatory Activity on 18FDG-PET/CT."],"pmcid":["PMC7943443"],"funding_grant_id":["T32 HL144909","K08 HL133474","R01 HL138628-01A1S1"],"pubmed_authors":["Baughman RP","Vagts C","Edafetanure-Ibeh R","Sweiss NJ","Huang Y","Ahmed S","Finn PW","Fraidenburg DR","Lu Y","Levin B","Ascoli C","Perkins DL"],"additional_accession":[]},"is_claimable":false,"name":"Unsupervised Clustering Reveals Sarcoidosis Phenotypes Marked by a Reduction in Lymphocytes Relate to Increased Inflammatory Activity on 18FDG-PET/CT.","description":"<b>Introduction:</b> Sarcoidosis is a T-helper cell mediated disease characterized by granulomatous inflammation. We posited that unsupervised clustering of various features in sarcoidosis would establish phenotypes associated with inflammatory activity measured by 18FDG-PET/CT. Our goal was to identify unique features capable of distinguishing clusters and subsequently examine the relationship with FDG avidity to substantiate their potential use as markers for sarcoidosis inflammation. <b>Methods:</b> We performed a retrospective study of a diverse, but primarily African American, cohort of 58 subjects with biopsy proven sarcoidosis followed at the University of Illinois Bernie Mac Sarcoidosis Center and Center for Lung Health who underwent 18FDG-PET/CT scan. Demographic, therapeutic, rad","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T15:24:34.254Z","creation":"2021-03-13T08:16:00Z"},"accession":"S-EPMC7943443","cross_references":{"pubmed":["33718397"],"doi":["10.3389/fmed.2021.595077"]}}