biostudies-literatureVagts CNHLBI NIH HHSNational Institutes of Health595077https://www.ebi.ac.uk/biostudies/studies/S-EPMC7943443biostudies-literatureUnknown8<b>Introduction:</b> Sarcoidosis is a T-helper cell mediated disease characterized by granulomatous inflammation. We posited that unsupervised clustering of various features in sarcoidosis would establish phenotypes associated with inflammatory activity measured by 18FDG-PET/CT. Our goal was to identify unique features capable of distinguishing clusters and subsequently examine the relationship with FDG avidity to substantiate their potential use as markers for sarcoidosis inflammation. <b>Methods:</b> We performed a retrospective study of a diverse, but primarily African American, cohort of 58 subjects with biopsy proven sarcoidosis followed at the University of Illinois Bernie Mac Sarcoidosis Center and Center for Lung Health who underwent 18FDG-PET/CT scan. Demographic, therapeutic, radFrontiers in medicineUnsupervised Clustering Reveals Sarcoidosis Phenotypes Marked by a Reduction in Lymphocytes Relate to Increased Inflammatory Activity on 18FDG-PET/CT.PMC7943443T32 HL144909K08 HL133474R01 HL138628-01A1S1Baughman RPVagts CEdafetanure-Ibeh RSweiss NJHuang YAhmed SFinn PWFraidenburg DRLu YLevin BAscoli CPerkins DLfalseUnsupervised Clustering Reveals Sarcoidosis Phenotypes Marked by a Reduction in Lymphocytes Relate to Increased Inflammatory Activity on 18FDG-PET/CT.<b>Introduction:</b> Sarcoidosis is a T-helper cell mediated disease characterized by granulomatous inflammation. We posited that unsupervised clustering of various features in sarcoidosis would establish phenotypes associated with inflammatory activity measured by 18FDG-PET/CT. Our goal was to identify unique features capable of distinguishing clusters and subsequently examine the relationship with FDG avidity to substantiate their potential use as markers for sarcoidosis inflammation. <b>Methods:</b> We performed a retrospective study of a diverse, but primarily African American, cohort of 58 subjects with biopsy proven sarcoidosis followed at the University of Illinois Bernie Mac Sarcoidosis Center and Center for Lung Health who underwent 18FDG-PET/CT scan. Demographic, therapeutic, rad2021-01-01T00:00:00Z20212025-04-05T15:24:34.254Z2021-03-13T08:16:00ZS-EPMC79434433371839710.3389/fmed.2021.595077