{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(2)"],"submitter":["Dai ZJ"],"pubmed_abstract":["<h4>Background</h4>Multiagent chemotherapy is the primary treatment for acute lymphoblastic leukemia (ALL), of which asparaginases including <i>Escherichia coli</i> L-asparaginase (<i>E. coli</i> L-Asp) and pegylated-asparaginase (PEG-Asp), are cornerstone components. The study aimed to conduct a meta-analysis to compare the efficacy and safety of PEG-Asp with <i>E. coli</i> L-Asp in Chinese children with ALL.<h4>Methods</h4>A systematic literature search was conducted to collect randomized controlled trials (RCTs) on PEG-Asp versus <i>E. coli</i> L-Asp in Chinese children with ALL. Two reviewers independently selected articles and extracted data. Risk-of-bias assessment was conducted with Cochrane recommendation tool. Pooled estimates and risk ratios (RRs) with 95% confidence intervals (C"],"journal":["Translational pediatrics"],"pagination":["244-255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7944179"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy and safety of PEG-asparaginase versus <i>E. coli</i> L-asparaginase in Chinese children with acute lymphoblastic leukemia: a meta-analysis."],"pmcid":["PMC7944179"],"pubmed_authors":["Dai ZJ","Lu Y","Huang YQ"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy and safety of PEG-asparaginase versus <i>E. coli</i> L-asparaginase in Chinese children with acute lymphoblastic leukemia: a meta-analysis.","description":"<h4>Background</h4>Multiagent chemotherapy is the primary treatment for acute lymphoblastic leukemia (ALL), of which asparaginases including <i>Escherichia coli</i> L-asparaginase (<i>E. coli</i> L-Asp) and pegylated-asparaginase (PEG-Asp), are cornerstone components. The study aimed to conduct a meta-analysis to compare the efficacy and safety of PEG-Asp with <i>E. coli</i> L-Asp in Chinese children with ALL.<h4>Methods</h4>A systematic literature search was conducted to collect randomized controlled trials (RCTs) on PEG-Asp versus <i>E. coli</i> L-Asp in Chinese children with ALL. Two reviewers independently selected articles and extracted data. Risk-of-bias assessment was conducted with Cochrane recommendation tool. Pooled estimates and risk ratios (RRs) with 95% confidence intervals (C","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-26T18:23:53.245Z","creation":"2025-02-19T01:40:11.267Z"},"accession":"S-EPMC7944179","cross_references":{"pubmed":["33708510"],"doi":["10.21037/tp-20-178"]}}