{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(4)"],"submitter":["Cummings MA"],"pubmed_abstract":["<h4>Background</h4>Squamous cell carcinoma of unknown primary of the head and neck region is a known entity described mainly by retrospective reports. We searched a hospital-based registry to better describe the changing incidence, and to assess diagnostic and treatment strategies.<h4>Methods</h4>The National Comprehensive Cancer Database was queried for head and neck cancers from oropharynx, tonsil, tongue, larynx, hypopharynx primary sites with a designation of clinical T0, representing an unknown primary. Kaplan Meier, Cox multivariate models, and propensity matched cohorts were used to assess significant factors for overall survival.<h4>Results</h4>There were 964 cases that met the criteria, and 468 cases with known treatments, staging, and survival data. The incidence increased over t"],"journal":["Annals of translational medicine"],"pagination":["284"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7944267"],"repository":["biostudies-literature"],"pubmed_title":["Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry."],"pmcid":["PMC7944267"],"pubmed_authors":["Singh AK","Cummings MA","Singh DP","Van Der Sloot P","Ma SJ","Milano MT"],"additional_accession":[]},"is_claimable":false,"name":"Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry.","description":"<h4>Background</h4>Squamous cell carcinoma of unknown primary of the head and neck region is a known entity described mainly by retrospective reports. We searched a hospital-based registry to better describe the changing incidence, and to assess diagnostic and treatment strategies.<h4>Methods</h4>The National Comprehensive Cancer Database was queried for head and neck cancers from oropharynx, tonsil, tongue, larynx, hypopharynx primary sites with a designation of clinical T0, representing an unknown primary. Kaplan Meier, Cox multivariate models, and propensity matched cohorts were used to assess significant factors for overall survival.<h4>Results</h4>There were 964 cases that met the criteria, and 468 cases with known treatments, staging, and survival data. The incidence increased over t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-04T19:24:21.711Z","creation":"2025-02-19T01:40:03.545Z"},"accession":"S-EPMC7944267","cross_references":{"pubmed":["33708911"],"doi":["10.21037/atm-20-4631"]}}